SI-101 is under clinical development by SIRPant Immunotherapeutics and currently in Phase I for Follicular Lymphoma. According to GlobalData, Phase I drugs for Follicular Lymphoma have a 78% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how SI-101’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

SI-101 overview

SIRPant-M is under development for the treatment of colon cancer, pancreatic cancer, head and neck cancer, cutaneous T-cell lymphoma and relapsed or refractory non-Hodgkin lymphoma, diffuse large b-cell lymphoma, mycosis fungoides, Sezary syndrome, anaplastic large cell lymphoma (ALCL), angioimmunoblastic T cell lymphoma, primary cutaneous follicle center lymphoma and primary cutaneous marginal zone B-cell, leg type, follicular center lymphoma, chronic lymphocytic leukemia (CLL) /small lymphocytic lymphoma (SLL), mantle cell lymphoma (MCL), nodal marginal zone B-cell lymphoma, non-melanoma skin cancers, bladder and kidney cancers, low-grade prostate cancer, triple-negative breast cancer and certain sarcomas . It is administered through parenteral and intratumoral route. The drug candidate comprises autologous polyclonal macrophages. They are being developed based on SIRPant technology.

SIRPant Immunotherapeutics overview

SIRPant Immunotherapeutics is a developer of novel autologous cell therapy for solid tumors. It is headquartered in Chambersburg, Pennsylvania, the US.

For a complete picture of SI-101’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 20 May 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.