Trotabresib is a small molecule commercialized by Bristol-Myers Squibb, with a leading Phase II program in Solid Tumor. According to Globaldata, it is involved in 5 clinical trials, of which 4 are ongoing, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of Trotabresib’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Trotabresib is expected to reach an annual total of $6 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Trotabresib Overview

CC-90010 is under development for the treatment of hematologic malignancies, solid tumors including advanced basal cell carcinoma, glioblastoma multiforme, diffuse astrocytoma, newly diagnosed glioblastoma, anaplastic astrocytoma, relapsed and/or refractory Non-Hodgkin lymphomas including diffuse large B-cell lymphoma, follicular lymphoma or marginal zone lymphoma. The therapeutic candidate is administered through the oral route. The drug candidate acts by targeting epigenetic target bromodomain and extra-terminal (BET) proteins. It was also under development for the treatment of NUT midline carcinoma, salivary gland carcinoma and endometrial carcinoma.

Bristol-Myers Squibb Overview

Bristol-Myers Squibb (BMS) is a specialty biopharmaceutical company that is engaged in discovery, development, licensing and manufacturing, marketing, distribution and sale of medicines and related medical products to patients with serious diseases. Its primary focus is on cancer, cardiovascular, immunology and fibrotic therapeutic projects. The company offers its products across the world to wholesalers, retail pharmacies, medical professionals, hospitals and government entities. BMS provides its products in the US, Europe, and Japan. The company conducts research to focus on the discovery and development of novel medicines that address serious diseases in areas of significant unmet medical need. BMS is headquartered in New York City, New York, the US.
The company reported revenues of (US Dollars) US$46,159 million for the fiscal year ended December 2022 (FY2022), a decrease of 0.5% over FY2021. In FY2022, the company’s operating margin was 20.9%, compared to an operating margin of 18.6% in FY2021. In FY2022, the company recorded a net margin of 13.7%, compared to a net margin of 15.1% in FY2021. The company reported revenues of US$10,966 million for the third quarter ended September 2023, a decrease of 2.3% over the previous quarter.

For a complete picture of Trotabresib’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 20 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.