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Antibody-Dependent Cell-mediated Cytotoxicity

Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) is a mechanism of immune defence attributed to the mode of action of several tab, in particular tumour cell targeting.

In ADCC, tumour cells (recognized by tab) are targeted by natural killer cells by their FcγRIII (CD16) receptor binding to the Fc portion of the tAb followed by lysis of the target (tumour) cell.

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