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What Is Liquid-Liquid Chromatography?

Most chromatographers first meet liquid chromatography through HPLC. A liquid mobile phase, a packed column, pressure, detectors, peaks, fractions, method development, troubleshooting. Familiar territory. Liquid-liquid chromatography, or LLC, keeps the chromatographic idea but changes one important part: the stationary phase is also a liquid. That single change affects how the separation works, what problems the method can solve, and why it is useful in industries working with complex, valuable, or sensitive mixtures.
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