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When Is Preparative Chromatography Actually Necessary?

Preparative chromatography is not automatically the next step after synthesis or extraction. It is one of several purification options alongside crystallisation, precipitation, extraction, distillation and membrane-based methods. Its purpose is to isolate a target compound at the quantity and purity required for further processing or use. The real question is therefore not whether chromatography can separate the mixture. It is whether the separation justifies its development time, solvent use and operating cost.
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