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August 20, 2021

Ronapreve: UK approves first-of-its-kind antibody cocktail to treat Covid-19

Phase III studies of the drug found it reduced the risk of hospitalisation or death in non-hospitalised patients by 70% compared with placebo.

By Darcy Jimenez

The Medicines and Healthcare products Regulatory Agency (MHRA) has approved the first monoclonal antibody treatment to prevent and fight Covid-19 in the UK.

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The decision to authorise Ronapreve, Regeneron and Roche’s casirivimab and imdevimab cocktail, was made after a review of clinical trial data showed the drug that may be used to prevent and treat acute Covid-19 infection and reduce hospital admissions due to coronavirus.

Phase III studies of the treatment found it reduced the risk of hospitalisation or death in high-risk, non-hospitalised patients by 70% compared with placebo. Ronapreve also reduced the duration of coronavirus symptoms from 14 to ten days in those with the virus.

Administered either by injection or infusion, the two virus-neutralising antibodies that form Ronapreve act at the lining of the respiratory system, binding tightly to the virus and preventing it from gaining access to respiratory cells.

Health secretary Sajid Javid said: “This treatment will be a significant addition to our armoury to tackle Covid-19 – in addition to our world-renowned vaccination programme and life-saving therapeutics dexamethasone and tocilizumab.

“We are now working at pace with the NHS and expert clinicians to ensure this treatment can be rolled out to NHS patients as soon as possible.”

Regeneron and Roche teamed up to develop and manufacture the two-antibody cocktail, originally discovered by Regeneron, in August 2020, with each company committing to dedicating a certain manufacturing capacity to the drug each year.

The treatment has been granted emergency use authorisation for the treatment of Covid-19 in over 20 countries, including the US, where it was authorised for adult and paediatric coronavirus patients in November.

Related Companies

Free Whitepaper
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What is the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry?

While wanting to protect the country from being overwhelmed by Omicron, China’s adherence to a Zero-COVID policy is resulting in a significant economic downturn. COVID outbreaks in Shanghai, Beijing and many other Chinese cities will impact 2022’s economic growth as consumers and businesses experience rolling lockdowns, leading to a slowdown in domestic and international supply chains. China’s Zero-COVID policy is having a demonstrable impact on consumer-facing industries. Access GlobalData’s new whitepaper, China in 2022: the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry, to examine the current situation in Shanghai and other cities in China, to better understand the worst-affected industry sectors, foodservice in particular, and to explore potential growth opportunities as China recovers. The white paper covers:
  • Which multinational companies have been affected?
  • What is the effect of lockdowns on foodservice?
  • What is the effect of lockdowns on Chinese ports?
  • Spotlight on Shanghai: what is the situation there?
  • How have Chinese consumers reacted?
  • How might the Chinese government react?
  • What are the potential growth opportunities?
by GlobalData
Enter your details here to receive your free Whitepaper.

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