MEDELPHARM

Tablet Press Manufacture for Compaction Simulation and Powder Analysis

MEDELPHARM is a high-precision engineering company manufacturing research and development (R&D) tablet presses and providing innovative solutions for powder analysis and formulation.

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About Us

MEDELPHARM is a specialist in the development, design, and manufacture of research and development (R&D) tablet presses and compaction simulators for powder compaction.

This high-precision engineering company provides intelligent tablet press technology and software development solutions for powder analysis and formulation.

MEDELPHARM focuses on the continuous development of innovative research and development presses (hardware and software), compaction simulation of industrial production cycles, powder characteriation and formulation services, compression, and material science. As compressed powders can be found everywhere, the applications encompass the pharmaceutical, cosmetics, food and nutraceuticals, chemistry & detergents, batteries & catalysts and explosives & nuclear industries.

R&D press for tablet development

The STYL’One Nano is the revolutionary benchtop R&D tablet press for demanding formulation scientists with price performance in mind. From API/excipient characterization, analytical development to formulation feasibility assessment and optimization, develop your single-layer formulation with only a few grams of powder.

Multi tip tooling on STYL’One Nano Benchtop Press.

Mini tablets patient-friendly systems for paediatric and geriatric applications.

STYL’One Nano Benchtop press powder zone and smart gravity feed shoe.

STYL’One Evo and STYL’One Nano R&D Presses.

STYL'One Evo Full Containment OEB 5 GMP installation.

External lubrication puff box and micro dosing unit.

Calibrated manual lubrication spray.

STYL’One Evo Dry Granulation and Roll Compaction mimicking

STYL’One Nano R&D Benchtop Press | Easy change of tooling.

The STYL’One Evo versatile compaction simulator is a high-speed, all-in-one single and multilayer tool designed for use in tablet development from early formulation to scale-up at production speed.

The machine characterizes essential powder properties and active pharmaceutical ingredients (API). It tests their suitability by simulating industrial production cycles, typically up to 400,000 tab/hour (dwell time <2ml), with only a few grams of powder needed.

The STYL’One Evo is designed for ease-of-use, compact footprint, and offers easy exchange of B, D (EU │TSM), oversized or core rods tooling. An optional micro-dosing unit, tab-in-tab device, GMP module with weight regulation, and force feeding are just a few of the available accessories offered with production mind.

More than 250 MEDELPHARM STYL’One units have been installed worldwide.

Quality by Design (QbD) R&D tablet press

QbD is a concept to produce a drug in a repeatable and cost-effective way. The QbD concept is in the heart of the design and development of the STYL’One R&D tablet press.

Machine operator protection during tablet production

With a global trend of powders being more and more potent, MEDELPHARM makes no compromise on user protection during tableting offering multiple solutions from wash-in-place to full containment OEB 5.

Dry granulation formulation development

Deciding on the right granulation process to meet your needs can be very material consuming. With the STYL’One Evo roller compaction simulation tool, you can identify the feasibility and impact of dry granulation directly at lab-scale with a limited amount of powder.

Training courses for tablet formulation and production

MEDELPHARM offers a range of training courses that are recognised by French authorities. The company aims to offer its extensive knowledge through effective training.

MEDELPHARM also offers its professional tableting instruments to various universities for training purposes so students can gain experience on current and future working methods. The company has university partnerships worldwide.

Maintenance, FAT, and SAT

MEDELPHARM offers services such as URS definition, installation, FAT, SAT, training and support, maintenance, and calibration, as well as consumables and wear and tear parts.

Powder processing solutions

MEDELPHARM distributes for France and Belgium renowned and innovative technologies in powder processing from lab scale to production, in association with partners worldwide, primarily KORSCH AG with its internationally renowned range of rotary presses.

Other collaboration partners include:

LB Bohle: Leading supplier of special process machines for weighing, granulation, sieving, blending, and coating.
Caleva: Market leader in manufacturing and developing equipment for the production of pellets (beads or spheroids) by extrusion and spheronization™
Fitzpatrick: Leading manufacturer of pharmaceutical hammer mills
MG2: Acclaimed Capsule filling equipment specialist and packaging solution manufacturer.
Quadro:Renowned manufacturer inventor of conical mills for consistent size reduction and uniform tableting.
ProCepT:Specialist offering innovative solutions for drying, agglomeration, tablet coating and mixing applications.

MEDELPHARM Science Lab

MEDELPHARM’s tableting and powder characterisation laboratory houses a team of research scientists and a range of sophisticated instrumentation dedicated to supporting clients with their product development needs. These include material characterisation, scale-up, small batch production, formulation, troubleshooting.

Innovative measuring equipment include STYL’One Nano and Evo compaction simulators, Smart Test 50, a CALEVA mini coater, a Quadro SLS multifunctional scalable lab system and a Comil U5, as an Accupyc (Micromeritics) Helium Pycnometer to measure true density, a turbula mixer, a disintegration bath and a friability tester.

About MEDELPHARM

Headquartered near Lyon, MEDELPHARM is a high-precision engineering company manufacturing R&D tablet presses and providing innovative solutions for powder characterisation and formulation.

Since 1985, MEDELPHARM is a specialist in tableting instruments ‘Made by people for people’, that work with high-speed and precision but at the same time are very easy-to-use. With its historical background in actual production, MEDELPHARM has a deep understanding of the R&D requirements that apply to tableting processes.

For formulation and pilot plant scientists around the world looking for assistance in powder characterisation, solid dosage formulation or production troubleshooting, MEDELPHARM can offer a comprehensive portfolio of versatile R&D presses and high-speed compaction simulators supported by a team of dedicated scientists.

Since the end of 2022, it has been a member of the international KORSCH Group, enhancing its worldwide reach.

White Papers

Containment: A Must-Have in Tableting

STYL’One stands for no compromise on tabletting analysis and no compromise on user protection from early research to multilayer production scale-up.

Lubrication: Now Easy-to-Use for R&D Lab Environment

Lubricants are often required to minimise friction between a tablet surface and the die walls during the ejection phase of the compression cycle.

STYL'One Nano: The Most Advanced Benchtop Tablet Press

Tableting has never been so easy and so powerful, from pure API characterisation to formulation assessment. Single-punch presses are ideal at formulation stage: easy to operate, easy to clean and for small amounts of API.

Tableting Complexity

Underestimating complexity underlies common problems in tableting. Modified release tablets are more complex than immediate release but no tablet is simple enough to never fail.

Formulation Development and Compaction of Itraconazole Amorphous Solid Dispersions Tablets Using Quality by Design Principles

Itraconazole (ITZ), a BCS Class II drug exhibiting low solubility (1-4ng/mL in water) requires formulation enhancement to achieve enhanced bioavailability. To tackle this problem, amorphous solid dispersions (ASDs) of ITZ in a polymer matrix (Kollidon® VA64) were produced using the Hot Melt Extrusion (HME) process.

A Fundamental Step in Your Tablet Development

Knowledge management based on data leads to avoid tablet defects in production and guarantee high production output. This can be undertaken right from the development stage thanks to STYL’One compaction simulators.

Assess the Impact of Your Granulation Process Parameters with The STYL’One Evo

This free white paper presents the methodology of MEDELPHARM Science Lab to study the effects of granulation critical process parameters on product quality attributes.

Rotary Tablet Press Simulation

How close is the simulation offered by MEDELPHARM's STYL'One to that of a rotary tablet press? Download this free PDF document to see some test results.

Effect of Precompression on Capping Tendency

Compaction simulators are a key technology allowing scientists to develop formulations and troubleshoot tablet defects.

Radial Die Wall Pressure Measurement

Instrumented die is used to measure maximum die-wall pressure (MDP) and residual die-wall pressure (RDP) during powder compaction.

Compaction Characterisation of Piroxicam Amorphous Solid Dispersions Formulations

Amorphous solid dispersions (ASDs) have been widely used to improve the bioavailability of poorly water-soluble drugs.

Design of Experiments (DOE): An Essential Tool to Better Understand Tablet Formulations

This free white paper covers a brief overview of the steps for pharmaceutical product development under the quality by design (QbD) framework; introduces design of experiments (DoE) applied to formulation of tablets and gives an example of how to design piroxicam amorphous solid dispersions (ASD) tablets using DoE.

Using the STYL’One Nano Compaction Simulator to Characterise Round and Oblong Itraconazole Amorphous Solid Dispersions Tablets

Itraconazole (ITZ) is an antifungal drug commercially available as an oral solution or more commonly as 100mg capsules. It has been reported that the bioavailability of the oral solution is only 55%.

Troubleshooting Tablet Defects in No Time

There are numerous tablet defects: chipping, picking and sticking, cracking, lamination, and capping to name a few.

Press Releases

KORSCH and MEDELPHARM Teams with LB Bohle for Complete Process Solutions Display at ACHEMA 2024

KORSCH and LB Bohle present their complementary technology at ACHEMA 2024 in Frankfurt am Main, Germany, in a shared booth. KORSCH, the global specialist in tablet press technology, complements with its innovations the processes delivered from Bohle to plan and map the entire tablet production process. Both companies offer world-class, complementary technology and have worked together on a wide range of projects involving integrated technology and process equipment trains.

MEDELPHARM and KORSCH Field Winning OSD Team at AAPS PharmSci 360 Florida

Research-based manufacturer and powder compaction specialists MEDELPHARM S.A.S. will showcase its advanced tablet research solutions at the American Association of Pharmaceutical Scientists annual meeting, AAPS PharmSci 360, in Florida.

MEDELPHARM STYL’One Evo DryCon® Execution Passes FAT and SMEPEC Tests

MEDELPHARM S.A.S. has successfully completed factory acceptance and particle containment testing for a high containment version of its industry-leading STYL’One Evo compaction simulator.

Korsch Cordially Invites You to Attend the World Premiere of Our New X 5 Tablet Press at 11am in Hall 16, Stand B 71 at Interpack

The X 5 is a single rotary press with a comparable footprint to the KORSCH flagship XL 400, but offers 20% more production capacity. The X 5 retains the KORSCH characteristic flexibility and quick-change design.

MEDELPHARM Forms Part of Combined Process Display at Interpack 2023

World-leading powder compaction simulation solutions from MEDELPHARM will form a key part of an impressive combined display of advanced pharmaceutical process technologies at the Interpack trade fair in Düsseldorf, Germany, from 4-10 May 2023.

KORSCH Acquires MEDELPHARM to Strengthen R&D Product Line

Innovative compaction simulator technology adds early-stage material characterisation and scale-up capability to the KORSCH R&D product portfolio.

Medelpharm to Present STYL’One Compaction Simulation at Making Pharmaceuticals Ireland

Research-based manufacturer and powder compaction specialists Medelpharm will showcase advanced tablet formulation possibilities offered by its STYL’One Nano benchtop research press platform at the upcoming Making Pharmaceuticals Ireland event in Dublin, Ireland.

MEDELPHARM Will Be Present at ACHEMA 2022, 22-26 August on KORSCH's booth A49/A71 in Hall 3.0

The MEDELPHARM team will be present at ACHEMA 2022 in KORSCH's booth A49/A71 in Hall 3.0 for live demos of the STYL'One Nano compaction simulator.

Medelpharm at the 13th PBP World Meeting, March 28-31 2022, Rotterdam, Booth 14, Congress Hall 2

MEDELPHARM will be present at the 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 28-31, Rotterdam.

Products & Services

STYL’One Evo: Tablet Press Provides Formulation Characterisation of APIs

This versatile machine is built upon the flexibility and multilayer capacity of the classic STYL'One and the speed and simulation function of the STYLCAM.