Bio Image Systems

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Gel Imaging and Analysis Software and Systems

Bio Image Systems provides imaging systems and software for companies in the pharmaceutical and biotechnology industries.

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721 Bloomfield,
Jackson, MI 49203,
United States of America
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Bio Image Systems develops powerful yet easy-to-use image analysis systems for pharmaceutical and biotechnology applications. Since 1982, we specialise in solutions for quality analysis (QA), quality control (QC), methods development, and research.

Analysis software for electrophoresis separations

Bio Image Systems’ Intelligent Quantifier-11 (IQ-11) is a software system for analysing scanned images of one-dimensional electrophoresis separations. Compatible with Windows 10 and 7, the program complies fully with 21CFR Part 11 regulations.

IQ-11 is accessible from analyst, supervisor, and administrator levels, as well as guarantees full data integrity through audit trails, two-factor signings, data versioning and other safeguards. The software is designed to minimise transposition errors and avoid linking off to potentially non-compliant applications.

Auto-calibrating scanners for sample analysis

Bio Image Systems provides scanners that can enable accurate quantitation and analysis across a range of samples. Our ACS-5000plus and ACS-6000 devices integrate a versatile Microtek scanner with our proprietary analysis software, including IQ-11, to offer fast and accurate analysis.

Bio Image Systems' scanners can be optimised for analysing a range of colour stains.
Our IQ-11 software analyses scanned images of one-dimensional electrophoresis separations.
The Bio-1000F fluorescent scanner works with the IQ-11 software to provide high-quality gel imaging.
Bio Image Systems' Bio Image FL-20BW camera is designed to analyse various blots quickly and accurately.

Both scanners operate across the whole visible spectrum (400nm-750nm) and can be optimised for various colour stains, while their 4.0 Dmax dynamic range enables accurate quantitation even in dark areas. They offer both transmissive and reflective modes and calibrate scans automatically to a step tablet that meets NIST regulations.

Fluorescent scanner for analysing non-toxic DNA stains

Bio Image Systems’ Bio-1000F fluorescent scanner offers sensitivity and versatility while being compact and cost-effective. The scanner works with our IQ-11 software application to provide high-quality gel imaging for non-toxic DNA stains.

The Bio-1000F works at a minimum sensitivity of 0.04ng for each band, using our patented optical design and blue LED to capture the faintest fluorescent signals. It also doubles as a gel excision station, removing the need to transfer your samples from the imager to the cutting platform.

Chemilluminescent camera for low-light analysis applications

Bio Image Systems’ Bio Image FL-20BW camera is designed to analyse western blots, slot blots, and dot blots quickly and accurately. The system combines a complementary metal oxide semiconductor (CMOS) camera with our proprietary, industry-proven Intelligent Quantifier® software.

Certain chemical reactions generate less light than samples treated with fluorescent labels, which can cause problems for traditional imaging solutions. The Bio Image FL-20BW addresses this by using a Peltier-cooled camera cooled to -20⁰C, with exposure times of up to an hour. In addition, its two-shelf imaging cabinet is designed and engineered to create a light-tight environment.

The camera can be used alongside our IQ-11 software to provide a solution that complies fully with 21 CFR Part-11 regulations and offers up-to-date data integrity capabilities.

Non-UV illumination solutions for safer analysis

Bio Image Systems offers four epi-illuminator devices that use harmless, visible LED light instead of ultraviolet (UV) rays, making them safe for eyes and skin while minimising damage to samples. These are the Epi-Green Pro, Epi-Green Slim, Epi-Blue Slim, and Epi-Blue Quad.

Our Epi-Green Pro and Epi-Green Slim devices come in single and twin configurations and can detect ethidium bromide (EtBr) stained gels, SYBR dyes, and GR Red and Green Loading Buffers. The Slim version can fit onto most gel-documentation systems and includes a pair of our sharp cut-off goggles to enhance imaging.

The Epi-Blue Slim epi-illuminator is ideal for detecting SYBR Green, Gold and Safe dyes, as well as EtBr stains. It fits most gel-doc systems and can also be used as a camera attachment.

Available in dual and quad configurations, our Epi-Blue Quad epi-illuminator is designed to detect chlorophyll and green fluorescent protein (GFP) in plants and small animals. Its light arrays can be adjusted from 2cm to 15cm, and it has an exposure time of 0.05 seconds.

White Papers

  • AI + IQ-11 = Faster 1D Gel Analysis

    Bio Image Systems can create an AI version of the Intelligent Quantifier-11 (IQ-11) software specifically for your samples and protocols. This could save your operators hundreds of hours or more.

Press Releases

  • AI IQ-11 Imaging Software from Bio Image Systems

    Are you using 1-D protein electrophoresis gels for QC release of antibodies and fusion proteins? Let Bio Image create an AI version of our Intelligent Quantifier-11 (IQ-11) software tailored specifically to your samples and it could save your operators hundreds of hours.

Products & services

  • IQ-11

    Intelligent Quantifier-11 (IQ-11) is a software system for analysing scanned images of 1-D electrophoresis separations. Available for Windows 10 and Windows 7, the software is fully compliant with 21CFR Part 11 as an integral part of the program. Analysis methods, standards, and report templates are developed at the Administrator access level.

  • AI + IQ-11 = Faster 1D Gel Analysis

    Together, we will combine our Intelligent Quantifier-11 (IQ-11) algorithms, used by customers around the world, with a training set of your gel samples to calibrate each sample, find its lanes, find and quantitate its bands, assign them standards values, and report results. It will work with blots, too. IQ-11 is fully compliant with 21 CFR Part-11.

  • Auto-Calibrating Scanners

    The Bio Image ACS-5000plus and ACS-6000 combine a versatile Microtek scanner with our industry proven Intelligent Quantifier®, Advanced Quantifier™, or Intelligent Quantifier-11™ software, to make a system which quickly and accurately analyzes your samples.

  • Fluorescent Scanner

    The Bio-1000F fluorescent scanner from Microtek offers sensitivity and versatility, is compact, and very affordable. Combined with our industry proven Intelligent Quantifier® software, you get the best gel imager available for non-toxic DNA stains!

  • Chemilluminescent Camera

    The Bio Image FL-20BW combines a Peltier-cooled CMOS camera with our industry proven Intelligent Quantifier® software, to make a system which quickly and accurately analyzes your western blots, slot blots, or dot blots. Or combine it with Intelligent Quantifier-11, to give you a fully 21 CFR Part-11 solution, with all the latest Data Integrity features.

  • Advanced Quantifier

    The Bio Image Advanced Quantifier (AQ) is a software system for analyzing scanned images of protein or DNA samples run in one-dimensional separations. These include Northerns, Southerns and Westerns, RAPDs, STRs (micro satellites), Paternity and forensic analysis using RFLPs or STRs, Strain identification and comparison using RFLPs or STRs, and other genetic mapping applications using 1-D molecular techniques.

  • Non-UV Illumination Products

    Bio Image Systems offers four epi-illuminator devices that use harmless, visible LED light instead of ultraviolet (UV) rays, making them fully safe for eyes and skin while minimising damage to samples. These are the Epi-Green Pro, Epi-Green Slim, Epi-Blue Slim, and Epi-Blue Quad.

  • Intelligent Quantifier

    The Bio Image Intelligent Quantifier (IQ) is a software system for analyzing scanned images of 1-D and 2-D electrophoresis separations, blots, and colonies/plaques. Using the IQ software you can analyze gel files obtained from protein, DNA, RNA, or blot samples and report the data.

Address
721 Bloomfield
Jackson, MI 49203
United States of America

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Brazil
BioAgency

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Canada
BioImager Inc
15 Connie Cre, Unit 5
Concord (Greater Toronto Area)
ON L4K 1L3 Canada

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Czech Republic, Slovakia
BIOTECH as
Hornokrèská 30
140 00 Praha 4

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Israel
Yair Technologies
Levinson 12, Gedera
Zip Code 70700, Israel

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Japan
RelyOn Limited
Mitsuai Bldg, Takekan 101
15-24, Takanawa 2-chome
Minato-ku, Tokyo 108-0074

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South Korea
Koreabiotech Co, Ltd
#514 Expo Officetel Mannyeon-dong
Seogu, Daejeon, Korea 302-834

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South America except Brazil
Optimización de Processos y Recursos (OPyR)
Caseros 2720
1678 Caseros, Buenos Aires Province
Argentina

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