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Case Study: Formulation Prototypes with Increased Solubility and Bioavailability

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Case Study: Formulation Prototypes with Increased Solubility and Bioavailability

By Catalent

Case Study: Formulation Prototypes with Increased Solubility and Bioavailability

By Catalent
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Catalent Pharma provided London-based pharmaceutical company Trio Medicines with three formulation technologies and four prototypes showing improved solubility and bioavailability for an acetyl prodrug of a novel, well-tolerated G-protein coupled receptor antagonist.

The company’s science and technology advisers utilised Optiform Solution Suite, an integrated platform with a structured three-step approach to assess, enhance, and deliver a formulation with suitable physical and chemical properties. Catalent conducted a series of assessments of the molecule’s physiochemical properties.

Find out more about Catalent’s assessment techniques, including chemical compatibility studies, molecule solubility and DCS classification, solid state characterisation, particle size by laser diffraction, and molecule stability by downloading this free whitepaper.

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