Medelpharm Tablet Press Solution for Powder Compaction Analysis and Manufacture
Medelpharm is a high-precision engineering company manufacturing research and development (R&D) tablet presses and providing innovative solutions for powder analysis and formulation.
The company focuses on continuous development of innovative research presses (hardware and software), simulation of industrial production cycles, powder characterisation and formulation services, compression, and material science in the pharmaceutical, food, and cosmetics markets.
Research press for the characterisation of raw materials and formulations for tablet development
The new STYL’One Evolution tableting instrument is a high-speed, all-in-one multilayer tool designed for use in tablet development from early formulation to scale-up at production speed.
The machine characterises essential powder properties and active pharmaceutical ingredients (API). It tests their suitability by simulating industrial production cycles, typically up to 400,000 tab/hour (dwell time <2 minutes), with only a few grams of powder needed.
No compromise on user protection from early research to multilayer production scale-up
Following a global trend, Medelpharm offers different levels of operator protection from wash-in-place to full containment OEL 5, for the most active ingredients.
Small-scale development in dry granulation
Dry granulation with roll compaction hybrid modelling is a topic intensively pursued by Medelpharm in close cooperation with the University of Düsseldorf.
QbD is at the heart of the development of tablet formulation
Quality by Design (QbD) is a concept to produce a drug in a repeatable and cost-effective way. This concept is in the heart of the design of the STYL’One R&D press.
High-power, adaptable software for powder compaction analysis
The ANALIS data acquisition and control package automatically explores and analyses the design of formula with efficiency in investigating critical attributes.
Collected data is analysed and presented in a user-friendly tabular or graphical format.
Compaction of tablets and analysis of powder properties but no trade-off in ease-of-use
The STYL’One Evolution is easy to use, with a compact, door-size design. It offers a clean and easy exchange of B, D (EU │TSM) oversized, core rods.
Valuable accessories are available such as the micro-dosing unit, a tab-in-tab device, a good manufacturing practice (GMP) module with weight regulation and force feeding, and a heated die.
STYLCAM / STYL’One has been installed more than 100 times worldwide.
Training to maximise capabilities in R&D and production
Medelpharm offers a range of training courses that are recognised by French authorities. The company aims to offer its extensive knowledge through effective training.
Medelpharm also offers its professional tableting instruments to various universities for training purposes so students can gain experience on current and future working methods. The company has university partnerships worldwide.
Maintenance, FAT, and SAT
Medelpharm offers services such as URS definition, installation, FAT, SAT, training and support, maintenance, and calibration, as well as consumables and wear and tear parts.
Powder processing solutions
Medelpharm distributes renowned and innovative technologies in powder processing from lab-scale to production with brands such as supplier of special process machines LB Bohle, manufacturer and developer of equipment for the production of pellets Caleva, and manufacturer of pharmaceutical hammer mills Fitzpatrick.
Conical mill for consistent size reduction and uniform tableting
Quadro is a tableting machine designed to provide uniform tableting. It evenly reduces the size of materials and has sieving, dispersion, and deagglomaration abilities.
Procept is a lab-scale R&D machine that specialises in drying, coating, agglomeration, and mixing applications.
Medelpharm is headquartered in Lyon, South-East France. Its team of experienced scientists provide powder characterisation services for screening of numerous formulations and testing powder flowability, powder densities, and tabletability.
In mid-2017, Medelpharm decided to leave its laboratory in the heart of the University of Lyon and built a laboratory on its own premises. This laboratory has a controlled atmosphere so it can perform powder characterisation and analysis. It also houses innovative measuring equipment such as the STYL’One Tableting Instrument, Smart test 50, a mini coater / drier for coating of minimal quantities of tablets, and an SLS multifunctional mill and sifter.
Distribution of the STYL’One Tableting instrument is part of a global partnership with the Romaco Group.
Products and Services
Extended Release Formulations: Using Multi-layer Tablets or Tab-in-Tab
Many options for the formulation of modified-release tablets, depending on the nature of the active pharmaceutical ingredient (API) and the required release profile.
Containment, a Must-Have in Tableting
Medelpharm's STYL-One does not compromise on tableting analysis or user protection from early research to multilayer production scale-up. Containment is a global trends. The principle 'better safe than sorry' is now the applied rule, which was generated by several factors.