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  1. Gamlen Instruments
5 December 2016

International Journal of Pharmaceutics Paper Features Gamlen’s R Series

Gamlen has announced some research data featured in the International Journal of Phameceutics Paper was collected using its R Series Research Compaction Analyser.

Characterisation of tableting properties measured with a multi-functional compaction instrument for several pharmaceutical excipients and actual tablet formulations is the latest paper to be published in the International Journal of Pharmaceutics detailing research undertaken using an instrument by Gamlen (IJP 510(2016) 195-202).

The paper was authored by leading tableting researcher Professor Osamura, with Yoshiko Takeuchi, Risako Onodera, Kohei Tahara, and Hirofumi Takeuchi, as well as Gifu Pharmaceutical University in conjunction with Masahiro Kitamura and Yoshiteru Takahashi of Sawai Pharmaceuticals.

Inventor of the Gamlen series of powder compaction instruments Michael Gamlen said: "We are delighted to learn of this latest publication. The R series provides precise data using tiny amounts of material, enabling a quick comparison of materials and formulations.

"Professor Takashi and his research colleagues examined the tableting properties of excipients and their findings confirm that the R series instrument (formerly known as the GTP-1) can be utilised in formulation design to determine excipient type, quantity and manufacturing conditions and to resolve tableting problems in scale-up."

Ideal for investigating problems and for teaching the principles of tableting, R series instruments are simple to use, computer controlled, benchtop powder compaction analysers.

Gamlen presents a study conducted by V. Penkavova1, L. Kulaviak1, M.C. Ruzicka1, M. Puncochar, and P. Zamostny on the 'Beaking of Anisotropic Rod-Saped Particles'.
The efficiency of downstream processing of active pharmaceutical ingredients (API) can depend on their particulate properties, including size and shape.
This whitepaper described a method for performing dynamic powder compaction analysis and for measuring tensile fracture strength of tablets.
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