Eurofins Genomics

Regulatory-Compliant Genomic Services

Anzinger Str 7a, D-85560 Ebersberg,Bavaria, Germany



Eurofins

Eurofins Genomics is a competence centre for genetic analyses of the Eurofins Scientific Group. The company has evolved into a reliable outsourcing partner for the biopharmaceutical industry and academic institutions for high-fidelity DNA sequencing and molecular biological techniques.

Eurofins Genomics has expanded to offer regulatory-compliant genomic services for pharmacogenomics / pharmacogenetics and biological safety testing. It is certified according to ISO:9001 and ISO:17025, and audited by pharmaceutical clients for GxP.

Comprehensive genetic analysis services

Eurofins Genomics has extensive experience in the application of different methods and techniques in the field of genetic analysis, which are crucial for the entire drug development and production process, starting from the preclinical phase through all clinical trials (phases I, II and III), to quality control for production of biologicals.

Eurofins Genomics offers a broad spectrum of services in the areas of analysis, research and development. We offer services for single samples, as well as for batches of a few to several thousand samples on high-throughput level. With our services, we help you develop agents and drugs more efficiently and economically, to use them optimally and precisely, and help avoid possible adverse effects. We also ensure the safety of the compounds through quality control during production.

All projects are discussed before providing a quotation to ensure a clear and precise understanding of your needs and requirements. Each project is planned thoroughly, with interim milestones scheduled, to ensure the highest probability for success.

Pharmacogenomics / pharmacogenetics and biological safety testing

Our pharmacogenomics / pharmacogenetics services portfolio covers:

  • DNA / RNA extraction
  • GLP-compliant genotyping and sequencing
  • SNP, mutation and biomarker analysis
  • Analysis of target genes
  • Expression analysis by real-time PCR
  • HT genotyping
  • Microarrays, e.g. SNP analysis and gene expression
  • Next-generation sequencing (NGS), such as tumour profiling / cancer sequencing, exome sequencing, transcriptome analysis and whole genome sequencing
  • Focus: G-proteins
  • Applications for pharmacogenomics / pharmacogenetics

Our biological safety testing services include:

  • Adventitious agent testing via next-generation sequencing
  • Genetic stability testing (GST)
  • Analysis of production strains and cell banks
  • Microbial detection and differentiation
  • Residual DNA testing
  • Cell line authentication via STR DNA typing

Our regulated services include:

  • Assay development and validation
  • Scientific consultancy during the planning and implementation of analyses in the scope of clinical trials
  • Expert advice on the evaluation and interpretation of results
  • Quality assurance and quality management following GxP guidelines
  • GLP-grade documentation (study plan and final report)
  • Project consultancy and project management

Technical devices for high-throughput analysis

We stock the following technical equipment:

  • Roche Genome Sequencers Junior and FLX/FLX+
  • Illumina MiSeq and HiSeq 2000 / 2500
  • Life Technologies Ion Proton
  • ABI 3730 XL 96/ 3100/3130 16 Capillary Sequencers
  • ABI TaqMan 7500, 7900HT, Low-density arrays (TLDA)
  • Roche Lightcycler LC 480 II
  • Fluidigm Biomark
  • Sequenom MALDI-TOF
  • Affymetrix 3000 G7 and GeneTitan
  • Illumina BeadStation and iScan
  • Beckman Pipetting Robots
  • Hamilton Robotic Systems
  • Perkin Elmer Chemagen Chemagic MSMI
  • Qiagen QIAsymphony, Universal Workstation, QIAcube

Pharmacogenetics and Pharmacogenomics

Pharmacogenetic and pharmacogenomic analysis of the effects of pharmaceutical compounds helps to realise the concept of individualised drug therapy or personalised medicine.

Adventitious Virus Testing Via Next-Generation Sequencing

Adventitious viruses are a major safety concern in biological products. For a substance to be considered free of an adventitious agent, assays must demonstrate that a defined quantity of the biological product is negative for an agent at a defined level of sensitivity.

Eurofins Genomics - Eurofins Medigenomix GmbH

Anzinger Str 7a

D-85560 Ebersberg

Bavaria

Germany

+49 8092 8289 200 www.eurofins.com/pharma-services/genomic-sequencing-services