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Freeze Drying Services, Training and Instrumentation

Biopharma House,
Winnall Valley Road,
SO23 0LD,
United Kingdom
Fax Number

BTL provides specialist services, training and advanced instrumentation in the field of freeze drying.

Pharmaceutical freeze drying

Freeze drying (lyophilisation) has applications in the preservation of many different types of materials, including chemicals, proteins, bacteria, nano- and micro- particles, polymers, liposomes, parenteral and non-parenteral drug formulations, high-value food products and supplements and coatings.

Common reasons for freeze drying include extension of shelf life, management of reactive properties, preservation of biological activity, preservation of tissues and cells, and as a concentration step. By controlling ice formation during the freezing stage, freeze drying can also be used to create products with specific pore size, for example collagen scaffolds.

Knowledge-based lyophilisation

BTL believes that successful freeze drying formulations and cycles should be developed through rational, knowledge-based practice.

Initial formulation analysis followed by sophisticated in-process monitoring and feedback enables us to design robust and efficient lyophilisation cycles in just a few runs.
Our production freeze drying capability allows a testing capacity or operational flexibility, with PC-controlled lyophilisers for post-process monitoring and analysis.
Lyostat freeze-drying microscope and Lyotherm DTA and impedance instrument provide information about the behaviour of products throughout the lyophilisation process.
BTL's training courses in freeze drying technology are designed to provide delegates with up-to-date information about all aspects of the process.

BTL’s freeze drying laboratory utilises a range of instruments and techniques to characterise products in terms of their freeze drying parameters in order to fully understand how they will behave before, during and after freeze drying. This ensures that cycles can be tailored to the specific needs of every product, making them efficient, safe, robust and reproducible.

Freeze drying services

The BTL team has decades of experience in the application of all aspects of freeze drying technology and has successfully processed over 700 different substances on behalf of clients. When taken together with our knowledge of pilot-scale and industrial freeze-dryers, we offer a uniquely comprehensive service covering all aspects of freeze drying from pre-formulation through to full-scale production and dried product analysis.

We aim to meet the precise needs of our customers’ projects, and will agree a work programme and a budget that is appropriate to the size and stage of your project. We are happy to run a single cycle or individual analysis for our clients, or agree a complete formulation and cycle development programme with you. Our philosophy is to augment your in-house expertise and work with you to make your project a success.

Freeze drying training, development and instrumentation

We offer a range of freeze drying services, as well as training, R&D and instrumentation. Our capabilities include:

  • Product characterisation of an existing product, to provide a scientific basis for cycle design or to troubleshoot a failing process
  • Formulation development, exploiting BTL’s knowledge of excipients and their cryo- and lyo-protectant properties to produce a formulation that is optimised for safe and efficient freeze drying
  • Freeze drying cycle development, to create a new freeze drying process for a new formulation or to optimise an existing process
  • Specialist analytical instruments for the characterisation of products in terms of their key freeze drying parameters
  • Product and process troubleshooting, in order to assess critical parameters and minimise batch failures
  • Training: BTL runs regular training courses worldwide, and is also able to offer on-site training specific to a customer’s requirements

BTL is keen to leverage its freeze drying process and engineering expertise in collaborative R&D projects. In the past two years, BTL has been awarded five grants by the UK government for feasibility studies and collaborative R&D projects focusing on applications such as the freeze-drying of blood, probiotics, collagen implants, herbicides and fusion proteins.

Press Releases

  • BTL Offers New and Improved Lyophilisation Training Courses

    Lyophilisation, or freeze drying, is an important process in many areas of research and production with applications in areas such as vaccines, diagnostics, regenerative medicine, functional foods, materials science and medical devices. For high-value products such as these it is vital to have a

  • Next-Generation Freeze Drying Microscopy from BTL

    BTL's freeze drying microscopes, the Lyostat series, have been popular for many years because of their speed and accuracy in returning useable data. Lyostat3, the latest in the series, features upgraded hardware and software and many options to offer enhanced reliability and flexibility, while ma

  • BTL Announces Lyo Instrumentation Training Sessions

    We are pleased to offer practical one-day 'refresher' sessions on the use of our freeze-drying microscopes, Lyostat3 and the previous model Lyostat2, and the Lyotherm2 thermal analyser. Lyostat and Lyotherm A rational, knowledge-based approach to designing and developin

  • BTL Offers Stabilisation Solutions for Diagnostic Products

    Many medical diagnostic products are not stable in liquid formulation. Diagnostic agents are by definition prone to reaction and change at both ends of the molecular size range. The benefits of freeze drying As a stabilisation method freeze drying offers many benefits.

  • BTL to Co-Host Free 'Emerging Technologies in Freeze Drying' Event

    BTL is pleased to co-host this free half-day event, highlighting some of the key technological advances in freeze drying. This meeting will showcase presentations highlighting the latest developments from academia and industry perspectives on the new frontiers of freeze drying and the p

  • BTL Appoints New Head of Sales

    Lyophilization specialist BTL is pleased to welcome Dr Laura Ciccolini as its new head of sales. BTL is a renowned expert in freeze drying (lyophilization) technology with a range of consultancy services for development, optimization and scale-up of products and processes. Freeze dryin

  • Lyophilization Training Course Dates for 2011

    Lyophilization specialist BTL is pleased to announce details of its training courses in lyophilization technology for 2011. Freeze drying is a complex science, requiring understanding and control of a number of different processes simultaneously. The difference between success and fai


Biopharma Technology Ltd
Biopharma House
Winnall Valley Road
SO23 0LD
United Kingdom

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