Founded in 1998, GL Biochem (GL) is a custom peptide synthesis provider and manufacturer of peptide raw materials such as linkers, resins, coupling agents and building blocks, as well as protective and unnatural amino acids and derivatives.

Our services and products also include custom organic synthesis, custom antibody services, protein expression and purification, contract research organisation (CRO), full-time employee (FTE) and chemistry manufacturing and controls (CMC) services, peptide libraries, catalogue peptides, generic peptides and active pharmaceutical ingredients (APIs).

The company has five manufacturing bases globally, with 12 offices and employs more than 1,500 staff worldwide.

Custom peptide synthesis services

GL provides custom peptide synthesis services to both research organisations and commercial industries, with more than 50% of our staff directly involved in peptide synthesis. We manufacture 10,000 purified peptides each month, from milligram (mg) to kilogram (kg) scale with peptide lengths up to 135AA, and over 600 kinds of peptide modifications and labelling options.

These include biotinylation, phosphorylation, cyclisation, glycosylation, methylation, sulfonation, fluorescence/dye labelling, isotope-labelling, Cy5 labelling, protein conjugation, special peptides (such as stapled peptides), peptoids and MAP branched peptides.

Protected amino acids, unnatural amino acids and derivatives

With a total of 350,000ft² of production space, 50,000ft² of research and development (R&D) centre and 10,000ft² of cGMP workshop, GL has some of the most comprehensive and diverse ranges of peptide reagents and building blocks product lines in the world.

We manufacture more than 10,000 building blocks for peptide synthesis and combinatorial chemistry, and R&D over a hundred new products every year by investing 15% of its annual revenue, one of the most comprehensive amino acid and related products producer in China.

Our product range includes fmoc, boc, N and Z protected amino acids, wang and 2-chlorotrityl resins, amino acid alcohols and coupling reagents, as well as unnatural amino acids, and natural amino acids and derivatives.

We also offer n-methyl amino acids, amino acid analogues and chiral building blocks, boronic acids/esters and rare chemicals, as well as pyridine-based and typical heterocyclic products.

Covid-19 peptides

GL stock Covid-19 related peptides and products for worldwide delivery, such as Covid-19 virus protease substrates peptides, including Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2, MCA-AVLQSGFRLys(Dpn)Lys-NH2 and Z-Leu-Arg-Gly-Gly-MCA; SARS-CoV-2 fusion inhibitor EK1, SARS-CoV-2 antigen peptides, Remdesivir

GL also has more than 3,000 catalogue peptides in stock for immediate shipment, ranging from generic peptides, cosmetic peptides, β-amyloid peptides, arginine-glycine-aspartate (RGD) peptides and pseudoproline dipeptides, etc.

Custom antibody services

GL offers a free consultation for antibody services and will analyse your protein and design the antigen peptide, as well as choose the most suitable package for your project.

Combining genomics, proteomics and structure genomics, the company has created an effective method for antigen design. GL guarantees that their antibodies, generated from antigen peptide, can be applied in Western blot.

There are 17 polyclonal antibody packages and six monoclonal antibody packages, as well as dozens of individual services, including protein express and purification for scientists to choose; customers who order custom antibody service from GL will enjoy lifetime technical support.

Chemistry, manufacturing and control services

GL supplies a range of chemistry, manufacturing and control services, such as process chemistry R&D, impurity synthesis and characterisation and formulation development and optimisation.

Furthermore, we can provide analytical method development and validation, generic medicine evaluation of consistent quality service, quality and stability studies, and registration affairs.

Support services for the pharmaceutical sector

GL has been offering CRO and FTE services to our global client base for more than two decades.

The company has highly competent teams and low user-to-instrument ratios to support all aspects of the drug discovery process.

A highly experienced team of 150 chemists, who have been working together for many years, allows GL for training, coaching and mentorship, which ultimately results in a depth of knowledge and expertise that supports the long-term success of projects.

The team focuses on problem-solving and efficiency to meet critical deadlines in dynamic drug discovery projects and offers:

• FTE or CRO
• Design and synthesis of analogues for lead generation / optimisation
• SAR analysis
• Optimisation of biological, metabolic and physical parameters
• Scaffold hopping and patent space analysis
• Preparation and scale-up of building blocks, scaffolds and starting materials
• Reference compounds and metabolites
• Design and synthesis of focused libraries