FPS Food and Pharma Systems Size-reduction Machines and Containment Solutions for API

Food and Pharma Systems (FPS) develops, manufactures, and installs fine size-reduction machines, as well as containment solutions of sterile and highly toxic active pharmaceutical ingredients (HPAPI).
FPS aims to develop, design, and supply systems to improve process results for the pharmaceutical and fine chemical industries.

Containment and cleanroom solutions for safe handling of pharmaceuticals

FPS’ systems meet a wide range of client needs and requirements due to the company’s approach of discussing any needs with the end user. Topics such as protection, productivity, and quality are considered to identify the most suitable solution.

FPS’ containment product portfolio includes isolators for the highest levels of protection, such as for sterile and toxic materials. For smaller volumes, laminar flow booths are available, as well as pack-off systems, which can safely discharge weigh and pack powders.

For general applications, FPS’ local extraction arms can reduce dust generation.

The company also offers a variety of cleanroom solutions, which includes partitioning walls, flooring with PVC mats, and co-planar surfaces.

Micronisation for fine grinding

FPS’ fluid jet mills and mechanical mills undertake micronisation processes to ensure high-quality fine grinding. The company’s experts can determine the best configuration for a client’s needs.

FPS’ micronisation product range includes spiral jet mills, the QMill, and the PinMill. Spiral jet mill technology is suitable for particle size distribution (PSD) below 3 µm, while the QMill and PinMill are better suited for PSD between 30 µm and 100 µm.

Spiral jet mill technology achieves size reduction by accelerating particles using high-speed jet streams. The particles are then collided to get a target PSD down to D90 µm < 3 µm.

Mechanical mills reduce pharmaceutical and chemical agglomerates to fine particles. FPS’ mills include a specially designed housing with an interchangeable stator and rotor.

QMill technology acts as an alternative to mechanical. Specifically designed for pharmaceutical applications, all connections are made in compliance with current good manufacturing practice (cGMP) standards and features quick assembly and disassembly. The number of components has also been reduced to a minimum to ensure easy cleaning and validation.

The spiral jet mill and QMill series are complete with dedicated feeding systems (volumetric or gravimetric) and final powder collection and filtration units.

Isolators for HPAPI production (containment down to nanogram levels), formulation, and packaging

Production and handling of highly potent active pharmaceutical ingredients (HPAPI) or toxic gases, liquids, and powders, require isolation to protect operators and the environment. In FPS’ isolators maintain a negative pressure regime and turbulent airflow is adopted. Containment levels between 0.01µg/m³ and 10µg/m³ can be achieved, with a variety of manufacturing solutions and configurations.

Any operator accessing the interior of the isolator must do so via its glove ports or half-suit.

Containment of HPAPI Oral Solid Form activity requires high-integration with the process machines without affecting functionalities and performance. The goal is to guarantee the best use of the process machines assuring high-containment capability.

The process is kept separated by means of closed rigid walls around the formulation machines. Suitable air barriers are provided when continuous operations are requested.

Dedusting machines and powder suction units are also proposed to be integrated inside the isolators to provide a higher containment.

Isolators for sterile applications

FPS also produces isolators for sterile applications. These are available as either closed isolators or restricted access barrier system (RABS). They allow operators to avoid the use of sterile cleanrooms and reduce the sterile volume in the process. Unidirectional or turbulent airflows can be used for ventilation.

Applications for FPS’ isolators include sterility testing, aseptic filling lines for pharmaceutical or food production, vessel charging of sterile products, and sterile milling and micronisation.

Integrated decontamination systems such as vapourised hydrogen peroxide (VHP) generators are also generally used.

Multi-milling platform

FPS proposes an innovative interchangeable milling station, which is used for milling operations in research and pilot plants. It contains different technologies integrated into a single system.

About FPS Food Pharma Systems

FPS produces high-quality systems and provides support through from initial discussions of a client’s needs to full-scale mock-up. The company can help clients comply to factory acceptance tests (FAT) and standardised measurement of equipment particulate airborne concentration (SMEPAC) tests, as well as assists customers after the delivery of equipment with maintenance and installation services.

As FPS machines are constantly evolving, its technical team is available to suggest possible upgrades and improvements. FPS employs about 50 people in Italy and has a wide network of agents, which assures a global presence.

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Press Release

Visit FPS at ISPE Exhibiton and Conference

Together with its local partner 1Supplier, FPS will be present at the next ISPE event.

White Papers

Micronisation and Milling

FPS is specialised in fine size reduction equipment and containment systems for many industrial applications.

Address
FPS Food and Pharma Systems

Via Vandelli, 20

Como 22100

Italy

+39 031 543429 +39 031 540885 www.fps-pharma.com

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Press Release

14 August 2018

Together with its local partner 1Supplier, FPS will be present at the next ISPE event.

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26 April 2018

FPS has announced it will be attending the ACHEMA trade fair, a worldwide forum and show for the process industries.

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3 April 2018

FPS has announced its presence at the forthcoming 2018 INTERPHEX (International Pharmaceutical Expo) event at the Javits Center in New York City.

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29 March 2018

FPS has announced it will be attending Pharmaconex 2018, Cairo, Egypt.

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21 March 2018

FPS has announced the delivery of a complex project that combines high containment within aseptic conditions.

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16 March 2018

FPS is proud to announce the opening of its new conference and training room, which will host a number of training events in the second half of 2018.

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6 March 2018

FPS and its local partner Codols Technology have announced they are to attend FarmaForum, Madrid, Spain.  

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1 February 2018

FPS has announced it is opening a new office in Philadelphia to support the continued growth of its business in North America.

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24 November 2017

FPS Food and Pharma Systems has announced it will be present at the annual appointment CPhI India in Mumbai.

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21 November 2017

FPS Food and Pharma Systems has received the OHSAS 18001 certification from independent company RINA.

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17 November 2017

FPS has confirmed its presence at Pharmtech & Ingredients show in Moscow.

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3 November 2017

F.P.S. Food and Pharma Systems has announced it will be attending the 54th CIPM China in Chansha.

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30 July 2017

FPS Food and Pharma Systems will be present at the annual appointment CPhI World Wide in Frankfurt.

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16 July 2017

FPS Food and Pharma Systems has announced its presence at the forthcoming 2017 POWTECH event at Nürnberg Exhibition Center.

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2 July 2017

FPS has announced it will be attending the 3rd Highly Potent Active Pharmaceutical Ingredients Summit in Barcelona.

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25 June 2017

FPS has confirmed its presence at Expoquimia, Barcelona.

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19 June 2017

FPS has announced its official partnership with the 14th edition of the World Mountain Running Long Distance Championships, Italy.

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28 May 2017

FPS is pleased to announce it will be exhibiting at the EXPO PACK 2017 trade fair, which takes place 13-15 June in Guadalajara, Mexico.

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25 May 2017

FPS has announced delivery of a high-containment Integrated system for an Oncology plant in Bangalore, India.

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30 April 2017

FPS will be attending the first Annual Formulation and Drug Delivery Congress, which will be held in London, UK, from 22-23 May 2017.

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3 April 2017

FPS has announced it will be attending COPHEX, one of Korea's leading pharmaceutical and cosmetic industry exhibitions.

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19 March 2017

FPS Food and Pharma Systems will be present at the annual PharmaCongress Production and Technology in Dusseldorf

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16 March 2017

FPS has announced it will show its latest innovations in micronisation and milling technologies for pharmaceutical, cosmetic, and chemical applications at Interphex New York.

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11 March 2017

FPS Food and Pharma Systems has announced its presence at the forthcoming 2017 INTERPHEX (International Pharmaceutical Expo) event at the Javits Center in New York City.

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19 February 2017

For the first time, FPS Food and Pharma Systems and its local partner will attend Asia Pharma Expo

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19 February 2017

FPS Food and Pharma Systems has announced it will be attending FarmaForum, an event for the pharmaceutical, biopharmaceutical, and laboratory technology industries.

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21 November 2016

FPS Food and Pharma Systems has announced it is expanding its production plant in Fiorenzuola d'Arda for greater flexibility and timeliness on production systems.

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23 October 2016

FPS Food and Pharma Systems has developed software, which controls equipment functionalities of a sterile micronisation system.

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28 September 2016

FPS Food and Pharma Systems will display its innovative solutions for containment and micronisation at CPhI in Barcelona.

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Regional Offices

FPS Food and Pharma Systems

Via Vandelli, 20

Como 22100

Italy

+39 031 543429 +39 031 540885 www.fps-pharma.com
Plant and R&D center

Via Romagnoli, 3

Fiorenzuola d'Arda 29017

Italy

+39 0523 984930 +39 0523 1652083

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