FPS Food and Pharma Systems

Size-reduction Machines and Containment Solutions for API

Via Vandelli, 20, Como 22100, Italy



Food and Pharma Systems (FPS) develops, manufactures, and installs fine size-reduction machines, as well as containment solutions of sterile and highly toxic active pharmaceutical ingredients (HPAPI).
FPS aims to develop, design, and supply systems to improve process results for the pharmaceutical and fine chemical industries.

Containment and cleanroom solutions for safe handling of pharmaceuticals

FPS’ systems meet a wide range of client needs and requirements due to the company’s approach of discussing any needs with the end user. Topics such as protection, productivity, and quality are considered to identify the most suitable solution.

FPS’ containment product portfolio includes isolators for the highest levels of protection, such as for sterile and toxic materials. For smaller volumes, laminar flow booths are available, as well as pack-off systems, which can safely discharge weigh and pack powders.

For general applications, FPS’ local extraction arms can reduce dust generation.

The company also offers a variety of cleanroom solutions, which includes partitioning walls, flooring with PVC mats, and co-planar surfaces.

Micronisation for fine grinding

FPS’ fluid jet mills and mechanical mills undertake micronisation processes to ensure high-quality fine grinding. The company’s experts can determine the best configuration for a client’s needs.

FPS’ micronisation product range includes spiral jet mills, the QMill, and the PinMill. Spiral jet mill technology is suitable for particle size distribution (PSD) below 3 µm, while the QMill and PinMill are better suited for PSD between 30 µm and 100 µm.

Spiral jet mill technology achieves size reduction by accelerating particles using high-speed jet streams. The particles are then collided to get a target PSD down to D90 µm < 3 µm.

Mechanical mills reduce pharmaceutical and chemical agglomerates to fine particles. FPS’ mills include a specially designed housing with an interchangeable stator and rotor.

QMill technology acts as an alternative to mechanical. Specifically designed for pharmaceutical applications, all connections are made in compliance with current good manufacturing practice (cGMP) standards and features quick assembly and disassembly. The number of components has also been reduced to a minimum to ensure easy cleaning and validation.

The spiral jet mill and QMill series are complete with dedicated feeding systems (volumetric or gravimetric) and final powder collection and filtration units.

Isolators for HPAPI production (containment down to nanogram levels), formulation, and packaging

Production and handling of highly potent active pharmaceutical ingredients (HPAPI) or toxic gases, liquids, and powders, require isolation to protect operators and the environment. In FPS’ isolators maintain a negative pressure regime and turbulent airflow is adopted. Containment levels between 0.01µg/m³ and 10µg/m³ can be achieved, with a variety of manufacturing solutions and configurations.

Any operator accessing the interior of the isolator must do so via its glove ports or half-suit.

Containment of HPAPI Oral Solid Form activity requires high-integration with the process machines without affecting functionalities and performance. The goal is to guarantee the best use of the process machines assuring high-containment capability.

The process is kept separated by means of closed rigid walls around the formulation machines. Suitable air barriers are provided when continuous operations are requested.

Dedusting machines and powder suction units are also proposed to be integrated inside the isolators to provide a higher containment.

Isolators for sterile applications

FPS also produces isolators for sterile applications. These are available as either closed isolators or restricted access barrier system (RABS). They allow operators to avoid the use of sterile cleanrooms and reduce the sterile volume in the process. Unidirectional or turbulent airflows can be used for ventilation.

Applications for FPS’ isolators include sterility testing, aseptic filling lines for pharmaceutical or food production, vessel charging of sterile products, and sterile milling and micronisation.

Integrated decontamination systems such as vapourised hydrogen peroxide (VHP) generators are also generally used.

Multi-milling platform

FPS proposes an innovative interchangeable milling station, which is used for milling operations in research and pilot plants. It contains different technologies integrated into a single system.

About FPS Food Pharma Systems

FPS produces high-quality systems and provides support through from initial discussions of a client’s needs to full-scale mock-up. The company can help clients comply to factory acceptance tests (FAT) and standardised measurement of equipment particulate airborne concentration (SMEPAC) tests, as well as assists customers after the delivery of equipment with maintenance and installation services.

As FPS machines are constantly evolving, its technical team is available to suggest possible upgrades and improvements. FPS employs about 50 people in Italy and has a wide network of agents, which assures a global presence.

Containment Solutions for HPAPI Production

Production and handling of high-potency active pharmaceutical ingredients (HPAPI) or toxic products in gas, liquid or powder form need total product separation from the environment to protect operators.

Open Factory 2019: a Super Day in FPS

On Sunday 24 November, FPS took part in the initiative promoted by L'Economia, a section of the famous Italian newspaper Il Corriere della Sera, opening the doors of its renovated production plant in Fiorenzuola d'Arda to hundreds of visitors.

FPS to Attend Open Factory on 24 November

In collaboration with The Economy of ‘Il Corriere della Sera’, FPS is pleased to announce its participation in the “Open Factory” event, which will take place on Sunday 24 November from 2:00pm to 7:00pm, at the FPS operational headquarters in Fiorenzuola d’Arda (PC).

FPS to Exhibit at the 30th edition of the CPHI WW in Frankfurt

FPS is pleased to announce its participation at the 30th edition of the CPHI WW in Frankfurt, the largest trade fair in the world, which brings together over 45,000 pharmaceutical industry professionals and 2,500 exhibitors from over 150 countries.

FPS to Present Third Micronisation Workshop

FPS will launch the third edition of its micronisation seminar, which will take place on 15 October 2019 at its operational headquarter in Fiorenzuola d’Arda, France.

FPS to Appear at Open Factory Event on 24 November

FPS, in collaboration with The Economy of Il Corriere della Sera, announces its participation in Open Factory, which will take place on 24 November, at the operational headquarters of FPS, in Fiorenzuola d'Arda (PC).

Micronisation Services by FPS

FPS is an Italian company specialised in the production of containment and micronisation systems for pharmaceutical, biotech and fine chemical companies.

FPS to participate at CIPM

FPS Food and Pharma Systems has confirmed its participation in the 57th edition of the CIPM event.

FPS to Participate at PHARMACONEX, Egypt

For the second year, FPS is pleased to participate in the 7th edition of the PHARMACONEX, one of the largest gatherings in the pharmaceutical sector in Egypt and the Middle East.

Visit FPS at CPhI India!

FPS Food and Pharma Systems has announced it will be present at the annual appointment CPhI India in Mumbai.

FPS to be Present at POWTECH

FPS Food and Pharma Systems has announced its presence at the forthcoming 2017 POWTECH event at Nürnberg Exhibition Center.

FPS to Exhibit at EXPO PACK 2017

FPS is pleased to announce it will be exhibiting at the EXPO PACK 2017 trade fair, which takes place 13-15 June in Guadalajara, Mexico.

FPS to Attend Interphex, New York

FPS has announced it will show its latest innovations in micronisation and milling technologies for pharmaceutical, cosmetic, and chemical applications at Interphex New York.

FPS Announces Production Plant Expansions

FPS Food and Pharma Systems has announced it is expanding its production plant in Fiorenzuola d'Arda for greater flexibility and timeliness on production systems.

FPS Food and Pharma Systems

Via Vandelli, 20

Como 22100

Italy

+39 031 543429 +39 031 540885 www.fps-pharma.com
Plant and R&D center

Via Romagnoli, 3

Fiorenzuola d'Arda 29017

Italy

+39 0523 984930 +39 0523 1652083