Stem Cell and iPSC Research Solutions
Stem cell models offer a renewable and biologically relevant source of human cells for studying disease mechanisms, evaluating drug candidates and investigating new cell-based therapeutic strategies. Creative Biolabs provides customised stem cell and induced pluripotent stem cell (iPSC) services for pharmaceutical, biotechnology and academic research programmes.
Our work covers cell reprogramming, line establishment, genome engineering, directed differentiation, characterisation, and the development of disease-relevant cellular models. Each project is planned around the intended application, required cell type and relevant biological endpoints.
iPSC generation and cell line establishment
Creative Biolabs can generate iPSCs from donor-derived somatic cells using integration-free reprogramming methods. Project design considers the starting cell type, reprogramming approach, clone selection criteria and intended downstream use.
Established iPSC lines can be assessed for cell morphology, pluripotency-marker expression, differentiation potential, genomic integrity and other quality attributes. Cell expansion, cryopreservation and banking are available to provide consistent research material for subsequent studies.
Custom differentiation
Reliable differentiation is essential when iPSCs are used to model tissue-specific biology. Creative Biolabs develops and applies differentiation protocols for a range of specialised cell types, including neurons, astrocytes, microglia, cardiomyocytes, hepatocyte-like cells, endothelial cells and immune cells.
Differentiated cells can be characterised using cell-type-specific markers, gene expression, morphology and functional assays. Culture conditions and maturation strategies may be adjusted according to the biological question and the level of cellular function required for the study.
Stem cell engineering
Genome engineering can introduce disease-associated variants, correct selected mutations or add reporters for tracking cellular responses. Creative Biolabs supports CRISPR-based editing of stem cell lines, followed by clone isolation, sequence confirmation and characterisation.
Where appropriate, gene-edited cells can be paired with an isogenic control. This approach reduces variability caused by genetic background and helps researchers examine the effect of a specific variant under comparable experimental conditions.
Disease modelling and drug discovery
Patient-derived and engineered stem cells can reproduce cellular features that are difficult to investigate using conventional immortalised cell lines. Creative Biolabs develops stem cell-based models for neurological, cardiovascular, metabolic, genetic and other disease areas.
These models can be used to study disease mechanisms, identify phenotypic changes and evaluate candidate interventions. Available applications include compound screening, dose–response studies, target validation, biomarker analysis, efficacy testing and mechanistic investigation.
Stem cell-derived cells can also support safety-related research. Depending on the cell type, studies may assess cytotoxicity, electrophysiological effects, mitochondrial function, cellular stress, inflammatory responses or other relevant endpoints.
Support for cell therapy research
For preclinical cell therapy programmes, Creative Biolabs provides support for cell-source selection, process development, expansion, differentiation and functional characterisation. Studies can be designed to examine identity, purity, viability, potency and phenotype, as well as relevant efficacy and safety-related endpoints.
Services are available as individual modules or as coordinated research programmes. Experimental plans, quality controls and deliverables are defined with the client to ensure that the resulting data address the project’s scientific objectives.
Contact Creative Biolabs to discuss a customised stem cell or iPSC research programme.
