ArmorFlex 114
Using single-use technologies to achieve continuous manufacturing has long been a goal of biomanufacturers.
ILC Dover
Flexible Powder Containment Technologies
ILC Dover offers flexible powder containment technologies, eliminating problems associated with the use of traditional metal and glass systems for the pharmaceutical industry.
Address
One Moonwalker Road,
Frederica,
DE 19946-2080,
United States of America
Frederica,
DE 19946-2080,
United States of America
Phone
ILC Dover offers flexible powder containment technologies, eliminating problems associated with the use of traditional metal and glass systems for the pharmaceutical industry.
The company applies flexible solutions to pharmaceutical potent powder containment during processing of bulk compounds and oral solid dosage manufacturing throughout the industry from North America to Europe and Asia.
Pharmaceutical powder containment
As demonstrated by the Risk-Based Manufacture of Pharmaceutical Products (Risk-MaPP) principles, both current good manufacturing practices (cGMP) and industrial hygiene (IH) needs can be met by containing the process at the source. By employing flexible containment and using the logic diagrams from the Risk-MaPP process, cleaning is minimised and the operator is protected with this engineering control. As such, processes in multi-product facilities can be safely performed without the risk of cross contamination.
Single-use powder handling systems
The DoverPac® containment system is a highly reliable storage solution for disposable products and single-use powders. Suitable for charging and offloading procedures, the system comprises a tough film liner supported by a durable fabric outer restraint.
The liners are formulated to meet client requirements, delivering high elongation performance for ruggedness and strength. This is complemented by a unique blend of anti-static additives, allowing for the safe and secure containment of pharmaceutical products.
Containment services for bulk compound processing
DoverPac® has gained wide acceptance by the pharmaceutical industry for use during processing of bulk compounds. DoverPac® prevents worker exposure to highly potent compounds and can eliminate the need for protective garments and respirators.
The new EZ Biopac is a contaminant and transfer system designed for easy adjustment to different bulk weights. Achieving a precice and quick fill time, the system keeps the discharge outlet seperate from antistatic polymer material resulting in 2g or less residule in a 5kg bag. In addition, the EZ Biopac has a protective bag to help ensure the support stand and exterior are not contaminated.
Continuous contained powder processing
ILC Dover’s flexible containment technologies allow continuous, contained processing utilizing ArmorFlex™ films developed specifically for the pharmaceutical industry. DoverPac® fabrication techniques are based on over 50 years of experience in life-critical product manufacturing.
Containment for potent compounds
Unlike standard flexible intermediate bulk containers that are not designed specifically for potent compound manufacturing, DoverPac® is designed to assist operators in performing operations without ever opening up the system. And, our ISO: 9001 registration assures product quality and operator safety during pharmaceutical potent powder containment operations.
Flexible containment systems
Flexible containment is a validated process that uses high-quality engineered storage products with a five-year shelf-life. They pass Chilworth incendivity tests, contain antistats to prevent powder sticking to the side of the bag, and have a drug master file (DMF) filed with the FDA.
FDA and EU compliant
ILC’s innovative ArmorFlex containment material is compliant with US Food and Drug Administration (FDA) and EU requirements:
- Complies with FDA 21 CFR
- Meets 2002 / 72 / EC requirements
- Passes USP 661 physicochemical tests for plastics
- Passes USP 88 class VI (7 day implant)
Flexible containment systems
Flexible containment is a validated process that utilises quality engineered products designed to meet critical requirements for:
- Five year shelf-life
- Permanent antistant replaces migrating additives
- Passes chilworth incendivity tests
- Drug master file (DMF) filed with FDA
Upgrade existing facilities for potent compound containment
DoverPac® is one of the fastest growing containment solutions in the industry. Our worldwide clients have appreciated the ability to upgrade existing facilities for potent compound containment during processing. This ability to upgrade has allowed our clients to avoid the capital expense of new equipment and / or facility upgrades. And, the fast turn around to facility upgrading for pharmaceutical containment has meant significant decreases in facility start-up times.
EZ BioPac
Today, manufacturers are optimising for open-suite facility designs to maximise throughput and profitability.
In-Process Isolator
ILC Dover develops flexible isolators (glove bags) for the pharmaceutical industry.
Doverpac Containment System
The DoverPac® Containment Systems are the global premier products for disposable process and powder containment systems.
Active Ventilation for Enclosures
Automated air controls for containment that protect people and the environment from exposure.
CrimpLoc by ILC Dover
The CrimpLoc® System provides high containment and secure closure when used with our ArmorFlex® films.
EZ BioPac Powder Transfer System
The EZ BioPac speeds up media and buffer production with modern single-use powder handling.
Development of a Disposable Grade-A Aseptic Fill/Finish Isolation System
While design characteristics may be identical to rigid stainless-steel isolators, flexible film aseptic isolators offer several advantages for careful consideration.
Improving the Safety and Efficiency of the Pharmaceutical Manufacturing Process
A pharmaceutical production line must be safely and efficiently managed above all else. If a product becomes contaminated or production is delayed, it can have severe ramifications for the manufacturer responsible.
ILC Dover Manufacturing Facility
In May 2019, ILC Dover opened a manufacturing facility in Ireland to produce the company’s pharmaceutical and biopharmaceutical product lines. The plant is designed to strengthen the company's single-use powder handling solutions business.
Bristol-Myers Squibb Manufacturing Plant, Devens, Massachusetts
In June 2006, US-based pharmaceutical company Bristol-Myers Squibb pledged to build a large-scale multi-product biopharmaceutical manufacturing plant in Devens, Massachusetts.
Eli Lilly Kinsale Pharmaceutical Manufacturing Facility
Eli Lilly made a commitment to invest approximately $400m in a biologics manufacturing facility in December 2006.
Wacker Chemie Biologics Production Facility
Wacker Chemie inaugurated a new production facility at its Jena site on 8 March 2010. Located approximately 90km south-w
CoreRX Tampa Facility Expansion
US formulation development company CoreRx Pharmaceuticals (CoreRx), initiated a major expansion of its manufacturing sit
Patheon Manufacturing Facility Expansion, Toronto
Canadian contract drug maker Patheon, completed the expansion of its Toronto manufacturing facility in April 2009, two m
SAFC Pharma API Manufacturing Expansion, Republic of Ireland
SAFC Pharma is a multinational operation, part of the US fine chemical company Sigma-Aldrich. SAFC specialises in provid
Bristol-Myers Squibb – Clinical Supplies Manufacturing
Bristol-Myers Squibb (BMS) has been undergoing much the same rationalisation process as many large pharmaceutical compan
Abbott Laboratories Biotech Facility, Puerto Rico
Puerto Rico has a growing reputation as a biotech and pharmaceutical hub ('Bio Island') and plays host to manufacturing facilities from the world's largest pharmaceutical companies.
Sanofi Pasteur Vaccine Production Plant, Swiftwater, Pennsylvania
Sanofi Pasteur, the vaccines business of Sanofi-Aventis, is one of the largest seasonal influenza vaccine producers in t
Roche Bulk Active Ingredient Manufacturing Facility, Florence, SC
Roche Carolina is the highly successful US subsidiary of pharmaceutical giant Hoffmann La Roche. Roche has operated a pr
Eli Lilly Biotech Pilot Plant, Indianapolis
In October 2006 Eli Lilly completed the first phase of its biotech facility expansion in Indianapolis, which was made re
Lonza Biotec
Lonza Biotec completed the construction of new manufacturing capacity with a multi-product design at Visp in Switzerland
Schering-Plough Production and R&D Facilities
Schering-Plough has continued to capitalise on its investment program into facilities based in Singapore. The company cu
Indena Anti-Cancer Compound Plant Automation
Indena SpA, an Italian company based in Settala near Milan, has announced plans to automate its plant for the production
Bristol-Myers Squibb’s Bulk Manufacturing Facility in Cruiserath, Ireland
In November 2000, Bristol-Myers Squibb began the construction of a new bulk manufacturing facility in the Republic of Ireland.
Novartis’ API Plant in Grimsby, West Yorkshire, UK
Novartis Pharmaceuticals' active pharmaceutical ingredients (API) plant complex in Grimsby, West Yorkshire, was first established in 1951.
Janssen Pharmaceutica’s Pharmaceutical Plant, Geel, Belgium
Johnson & Johnson (J&J) subsidiary Janssen Pharmaceutica decided to build a new pharmaceutical plant in Geel in Belgium in 1998.
Glaxo Wellcome Anti-Infective Drugs Plant, Suzhou, China
In 1998, Glaxo Wellcome made an investment in a production facility in Suzhou in the eastern Chinese province of Jiangsu.
Process Control Update at Cedarburg’s Intermediate and API Facility, Grafton, US
Cedarburg Pharmaceuticals awarded Emerson Process Management with a contract in 1998 to supply the company with process controls for its new facility in Grafton, Wisconsin, US.
AstraZeneca Pharmaceuticals Complex, Södartälje, Sweden
The project is a pharmaceuticals plant located at Snackviken, in Södartälje, Sweden. It is owned by AstraZeneca, which was formed by a merger of Swedish Astra and British Zeneca.
AstraZeneca Large Scale Laboratory (LSL) Facility, Macclesfield, UK
AstraZeneca's large-scale laboratory (LSL) project was instigated as a brownfield development in Macclesfield, UK.
ILC Dover Acquires Solo Containment
ILC Dover, a global leader in the development of single-use flexible solutions for pharmaceutical manufacturing, is pleased to announce the acquisition of UK-based Solo Containment (Solo), a specialist manufacturer of flexible film isolators.
10 September 2020ILC Dover Introduces Atmospheric Control Module to Safely Contain Highly-Potent Active Pharmaceutical Ingredients
ILC Dover, a world leader in the innovative design and production of engineered products employing high-performance flexible materials, introduced the Atmospheric Control Module (ACM) designed to provide additional risk mitigation and enhanced processing control for highly-potent active pharmaceutical ingredients (HPAPIs) within laboratory areas and GMP operations.
2 September 2020Apollo Continues its Bold Innovation at ILC Dover
The 50th anniversary of the Apollo 11 moon landing draws near and ILC Dover’s ‘Beyond Boundaries™’ culture continues the bold innovation that put humans on the moon and brought them safely back to earth.
5 August 2019Helping Biopharma Create Life-Changeing and Life-Saving Drugs
The circumstances that gave birth to the biopharmaceutical industry are the same circumstances that present one of its key challenges: contamination.
30 May 2019ILC Dover Opens New Production Facility in Cork
Member of the European Parliament (MEP) Deirdre Clune officially opened ILC Dover's new manufacturing facility in Blarney Business Park, Cork alongside ILC Dover CEO and President Fran DiNuzzo.
23 May 2019ILC Dover to Attend Interphex
ILC Dover has announced that it will be showcasing its containment solutions at Interphex.
15 March 2019ILC Dover to Attend Annual MDCHPC Event
ILC Dover has announced it will be showcasing its powder containment technologies at the 9th Annual Miami-Dade County Healthcare Preparedness Coalition Symposium.
6 March 2019ILC Dover to Open New Production Facility in Blarney, Ireland
Flexible containment solutions provider ILC Dover is expanding its Irish production footprint by opening a location in Blarney, County Cork, Ireland.
2 November 2018ILC Dover to Attend INTERPHEX, New York, US
ILC Dover has announced that is will be attending the INTERPHEX tradeshow in New York, US.
9 April 2018Rapid Mixing of Pharmaceutical Powders
ILC Dover has proven the efficacy of its new semi-automated system, which is designed to disaggregate powdered media and buffer powders for superior mixing into a solution.
22 August 2017ILC Dover Performs an RX-360 Audit
ILC Dover has successfully completed an Rx-360 pharmaceutical industry consortium audit for its packaging and supply chain security.
14 March 2017ILC Dover Completes Acquisition of JetSolutions
ILC Dover has announced that it has acquired JetSolutions in Rossens, Switzerland.
14 September 2015ILC Dover Introduces New CrimpLoc™ System
The new CrimpLoc system is the next generation to provide high containment, secure closure, and easy one-piece crimp removal without any breaking or risk of plastic shards.
4 July 2013ILC Dover to Exhibit at Powtech 2013
ILC Dover welcomes you to our exhibit at Powtech 2013. We will be located in hall 1 at booth 645 for the event in Nürnberg, Germany, which will take place 23-25 April 2013.
17 April 2013New and Improved Crimps for DoverPac Containment Systems
LC Dover is committed to continuous improvement and listening to our customers. We first invented flexible high containment in 1997 and immediately improved the old standard of twist, tie, tape and cut for the separation of the flexible by inventing the crimp system.
12 March 2013ILC Dover Introduces Premier Closure System in Pharmaceutical Processing – CrimpLoc System
ILC Dover pioneered flexible containment for the pharmaceutical industry and continues to innovate processes for better performance. We invented the original crimping system and now we have created the CrimpLoc System.
19 September 2012See What’s Next in Powder Containment at ISPE Brussels, Belgium, with ILC Dover
ILC Dover would like to invite you to attend the 2012 ISPE Conference in Brussels, Belgium, at the Thon Hotel Brussels EU, 17 to 18 September 2012. ILC Dover regional sales manager for Europe, Malcolm Cunningham, will be co-hosting this event and presenting a paper.
30 August 2012ILC Dover to Present Flexible Containment Solutions at Interphex
As the leader in flexible containment, ILC Dover offers state-of-the-art containment technology.
18 April 2012ILC Dover, CSV Life Science and Jet Solutions to Co-Exhibit at CPHi Worldwide
You are invited to visit ILC Dover at the 2011 CPHi Worldwide Show in Messe Frankfurt, Germany, on 25-27 October 2011.
17 October 2011ILC Dover’s Sentinel XL Clear™ Hood Powered Air Purifying Respirator Now Available for a No-Obligation Trial
ILC Dover's NIOSH-approved Sentinel XL Clear™ Hood Powered Air Purifying Respirator (PAPR) is used in applications that are not using containment and where a combination of flexible containment and RPE support a process.
11 October 2011ILC Dover and Jet Solutions to Co-Exhibit at Powtech
You are invited to visit us at the 2011 Powtech Show in Nuremberg, Germany, on 11-13 October 2011.
4 October 2011The ILC Dover Weigh and Dispense System: A New Era in Dispensing Technology
The ILC Dover weigh and dispense system is a new era in dispensing technology. This modular design has been developed to allow weighing or subdividing materials in a highly contained way while maintaining weighing accuracy. The system can be used for weighing and then directly charging
27 July 2011ILC Dover Now Offers Advanced Respiratory Protection Products – On Show at AIHce 2011
Talk with the ILC Dover RPE and flexible containment experts about your industrial hygiene challenges at the annual AIHce show in Portland, OR, at the Oregon Convention Center, 16-18 May 2011, at booth 1647. On display you will see: Sentinel Clear™ Hood PAPR System
2 May 2011ILC Dover to Showcase New Containment Equipment at Interphex
As the leader in flexible containment, we offer state-of-the-art containment technology. The DoverPac® films, designs and applications are accepted as the most cost-effective method to achieve high containment. See us at Interphex to discuss your applications and our proven solutions, expect
8 March 2011Contained Blending – Flexible Enclosure Technology
The systems described here center around bin blending and V-Blender applications in oral solids dosage (OSD) manufacturing using flexible enclosures. Blending involves the controlled mixing of dry primary powder particles and excipients. The powders can range in properties and potency and, if not
14 December 2010Contained Blending – Transfer Sleeve, DoverPac®, Continuous Liner Technology
The systems described here center around bin blending and V-Blender applications in oral solids dosage (OSD) manufacturing using flexible enclosures. Blending involves the controlled mixing of dry primary powder particles and excipients. The powders can range in properties and potency and, if not
14 December 2010ILC Dover Introduces Process Area Barrier Curtains
Process area barrier curtains are a useful tool in improving the containment levels in existing installations as a method to reduce operational exposure risk and to restrict access. Examples of these types of applications include, but are not limited to, down flow booth curtains and room access b
31 October 2010DoverPac® Flexible Enclosure on O’Hara Tablet Coater at the 2010 AAPS Show
O'Hara Technologies will be displaying the DoverPac® flexible enclosure manufactured with clear ArmorFlex® film on their tablet coater at the 2010 AAPS Annual Meeting and Expo in New Orleans, US, at booth #1133.
7 October 2010ILC Dover Advances Media and Buffer Prep Powder Handling
ILC Dover has announced that its DoverPac® SF family is advancing the state-of-the-art in buffer/media preparation for the biopharmaceutical industry with these single use, flexible systems. By using ILC's durable ArmorFlex® materials, 3D disposable vessels have been created
16 September 2010ILC Dover to Exhibit its Flexible Powder Containment Technologies at INTERPHEX
ILC Dover's flexible powder containment technologies eliminate many of the problems associated with the use of traditional metal and glass systems for the pharmaceutical industry. To find out more about ILC Dover's flexible powder containment technologies visit the company at stand 303
8 April 2010Flexible Containment with the Bohle BTS 100 Mill Containment System
Particle size reduction is commonly required in pharmaceutical manufacturing. Taking into account today's need to mill highly hazardous compounds in conjunction with the need to minimize capital cost spending, the application of flexible containment to an existing Bohle BTS 100 sieve design demon
17 November 2009ILC Dover Introduces Revolutionary New Contact Film
Frederica, DE – ILC Dover has announced the introduction of a new permanent antistat contact film - ArmorFlex® 114. The rugged ArmorFlex family of films has been the recognized gold standard for materials of contact within the pharmaceutical industry since 1997. ILC
5 October 2009Flexible Containment Solutions: Tray Dryer Enclosure Technology
Tray dryers are a common method of drying wetcakes and granulated drug products, especially in the early product development phase. The issue of containment for this type of process equipment is unique in that open scooping of powder on to multiple trays that get slotted into the dryer one at
28 June 2009DoverPac™ Flexible Containment Systems are Compliant with the REACH Regulation
As the leader in flexible containment and disposable cGMP systems, ILC Dover, with the assistance of an independent third party consultant, has reviewed the products they offer to the pharmaceutical industry with regard to the REACH (Registration, Evaluation and Authorisation of Chemicals) regula
6 May 2009ILC Dover to Attend Interphex 2009
Cutting edge flexible containment technologies are a proven solution to achieve containment for retrofit applications, and can be seen at ILC Dover’s stand (number 946) at Interphex in New York from 17 to 19 March 2009. Today’s marketplace and overall economy are putting more pressure t
1 March 2009Coverage area: Europe
JetSolutions
- Daniel Leva
- +41 26 492 68 00
- levad@ilcdover.com
- www.ilcdover.com
Telephone Number
Fax Number
Email Address
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ILC Dover LP
One Moonwalker Road
Frederica
DE 19946-2080
United States of America
- +1 302 335 3911
- +1 302 335 1320
- customer_service@ilcdover.com
- www.ilcdover.com
- Podcast on Flexible Containment in Pharmaceutical Industry
Telephone Number
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