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  1. EULAR 2018: key pipeline developments in psoriatic arthritis
  2. Lanabecestat termination: another blow for BACE inhibitors
  3. EULAR 2018: Focus on infliximab biosimilars in rheumatoid arthritis
  4. Northwest Bio’s DCVax-L: is the hype warranted for glioblastoma patients?
  5. ASCO data sees Merck’s Keytruda pull ahead of Roche’s Tecentriq in lung cancer

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Lanabecestat termination: another blow for BACE inhibitors

After the disappointing failures of highly anticipated anti-amyloid pipeline drugs, such as Pfizer/Johnson & Johnson’s bapineuzumab and Eli Lilly’s solanezumab, the focus of research in Alzheimer’s has increasingly turned to beta-secretase (BACE) inhibitors. Unlike the injectable monoclonal antibodies, the BACE inhibitors are oral small molecules.

EULAR 2018: Focus on infliximab biosimilars in rheumatoid arthritis

On June 14th, Biocad presented Week 14 results on the safety and efficacy of BCD-055 (infliximab biosimilar) from the ongoing Phase III LIRA clinical trial. The international, multicenter, double-blind, placebo-controlled trial randomised (2:1) 426 adult patients with active rheumatoid arthritis (RA) to receive BCD-055 or infliximab innovator for 54 weeks both at a dose of 3mg/kg. At Week 14, 71.6% of patients receiving BCD-055 compared with 67.9% of patients receiving Remicade achieved American College of Rheumatology 20% improvement criteria (ACR20) (p=0.587).

The ten most promising cancer drugs being trialled

To meet rising demand, companies worldwide are striving to develop cost-effective and innovative therapies for a wide variety of cancer types. Pharmaceutical-technology.com lists some of the most promising oncology drugs that are currently undergoing late-stage clinical trials.

Northwest Bio’s DCVax-L: is the hype warranted for glioblastoma patients?

Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer; little progress has been made toward its treatment in the past decade. However, on May 29 Northwest Bio revealed Phase III interim data for its personalised autologous dendritic cell vaccine, DCVax-L, outlining highly encouraging survival data for newly diagnosed glioblastoma patients.

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