Metrohm Titration, Voltammetry and Ion Chromatography Services

Metrohm is the global market leader in the fields of titration and voltammetry, and one of the leading innovators in ion chromatography, online analysis and laboratory automation.

Metrohm is the only company providing all relevant ion analysis technologies under one roof: potentiometric and Karl Fischer titration, voltammetry and ion chromatography, as well as pH, ion, conductivity and oxidation stability measurements. Additionally, we offer instrument software, method-specific software packages, and peripheral units, as well as a full range of systems for dosing and liquid handling.

Customised analysis for the pharmaceutical industry

With regard to the quality and safety of drugs, authorities worldwide set high standards for the pharmaceutical industry. These are documented in pharmacopoeias in the form of official collections of recognised pharmaceutical rules. As legal tools of consumer protection, they ensure that drugs are used safely.

To ensure these high quality and safety standards, reliable instruments and methods are needed.

Instruments for titration, ion chromatography and pH measurement

As a leading manufacturer of instruments for titration, ion chromatography and pH measurement, Metrohm is aware of these challenges. For this reason, Metrohm offers you not only the latest instruments, but complete solutions for very specific analytical issues.

Your Metrohm contacts are competent specialists, who will develop customised applications and provide you with professional support in all matters of regulatory compliance.

Discover what solutions Metrohm is able to offer the pharmaceutical sector, and you in particular, to ensure the quality and safety of your products.

Intelligent titrator without reliability gaps

Thanks to its modular concept, the Titrando system can easily be adapted to any application. It meets the requirements of FDA regulation 21 CFR Part 11, irrespective of its use as stand-alone titrator in combination with 840 Touch Control, PC Control or tiamo™.

The advantages at a glance:

  • Brainy dosing elements with certification
  • The iTrodes – intelligent electrodes
  • STAT titration with tandem dosing
  • Flexibility – from the individual instrument to the fully automated system
  • Sample preparation at the touch of a button

Automatic sample preparation instruments

With instruments of the Robotic Soliprep family, neither deviant results nor time-consuming manual routines are an issue. The solid substance is simply weighed out and placed in the sample rack – all the rest is done fully automatically.

Depending on the model selected, different steps can be combined – including the direct connection to a chromatograph or the titration of the homogenised sample.

Ion chromatography systems

Ion chromatography is the method of choice to determine active ingredients, excipients and traces of impurities and metabolites in the form of organic and inorganic ions or polar substances in a number of pharmaceuticals, pharmaceutical solutions or body fluids. In particular, Metrohm ion chromatography systems handle demanding analytical challenges such as the determination of impurities in pharmaceuticals, active pharmaceutical ingredients and pharmaceutical solutions.

Metrohm has taken ion chromatography to an entirely new level. The 850 Professional IC is the first ion chromatography system made up of intelligent components.

Measuring stand for voltammetric and polarographic determinations

Voltammetry also enables organic compounds to be determined with a high degree of sensitivity. This makes it possible to analyse many active pharmaceutical ingredients according to USP<801>.

The 797 VA Computrace is a modern measuring stand that allows voltammetric and polarographic determinations to be performed.

Some application examples:

  • Fe(II) in iron sucrose injection solution according to USP-NF
  • Thimerosal in eye or nose drops, vaccines and cleaning solutions for contact lenses according to USP-NF
  • Heavy metal impurities in pharmaceutical products

Metrohm is exclusively represented in more than 80 countries, more than 40 of which have their own subsidiaries. This guarantees a tight network for sales and service.

Make an enquiry

Address
Metrohm AG

Oberdorfstrasse 68

9101 Herisau

Other

Switzerland

+41 71 353 8585 +41 71 353 8901 pharma.metrohm.com www.metrohm.com

Metrohm Images

Products and Services

Video

White Papers

Related Projects



Bristol-Myers Squibb Manufacturing Plant, Devens, Massachusetts



In June 2006, Bristol-Myers Squibb made a commitment to construct a new large-scale multiproduct biopharmaceutical manufacturing plant in Devens, Massachusetts, US.

29 May 2016

Novartis Vaccine Manufacturing Facility, North Carolina



In July 2006 Novartis announced that it would build a new vaccine manufacturing facility in Holly Springs, North Carolina, US.

21 March 2013

Eli Lilly Kinsale Pharmaceutical Manufacturing Facility



Eli Lilly made a commitment to invest approximately $400m in a biologics manufacturing facility in December 2006.

29 December 2011

Merrion Biopharma Research and Development Laboratories



Merrion's new R&D facility located in Citywest, south Dublin, Ireland is a state-of-the-art facility designed to accommo

21 December 2009

Genzyme Manufacturing Expansion



Genzyme Corporation is one of most prominent biotechnology companies in the US. Based in Cambridge, Massachusetts, it wa

17 December 2009

Novartis Pharmaceutical Development Centre



On 2 November 2009, Novartis officially opened its new global technical centre Suzhou Novartis Pharma Technology Co in R

8 December 2009

Novartis Institute of BioMedical Research



The Novartis Institute of BioMedical Research (CNBIR) is located in the Zhangjiang High-Tech Park in the Pudong New Area

29 November 2009

University of Maryland Biopark



The University of Maryland in Baltimore has developed a state-of-the-art BioPark on the urban campus of the university.

25 November 2009

Cambrex Profarmaco, Paullo



Cambrex Profarmaco, Cambrex's Milan facility, is a cGMP manufacturing facility located 25km southeast of Milan, Italy. T

13 October 2009

Pronova Biopharma Pharmaceutical Production Facility



Pronova BioPharma is one of the leading companies in the research and development of marine-originated omega-3 fatty aci

29 September 2009

Norwich Pharmaceuticals Norwich Facility



A leading provider of contract manufacturing and packaging services, Norwich Pharmaceuticals has served the pharmaceutic

14 September 2009

GSK Biologicals Manufacturing Plant



The vaccine manufacturing plant of GlaxoSmithKline (GSK) in Dresden, Germany mainly produces the company's seasonal infl

10 August 2009

GSk Vaccine Manufcaturing Plant, St Amand Les Eaux



GSK Biologicals, the vaccine division of the pharmaceutical and healthcare company GlaxoSmithKline (GSK), announced its

20 July 2009

CoreRX Tampa Facility Expansion



US formulation development company CoreRx Pharmaceuticals (CoreRx), initiated a major expansion of its manufacturing sit

16 July 2009

Patheon Manufacturing Facility Expansion, Toronto



Canadian contract drug maker Patheon, completed the expansion of its Toronto manufacturing facility in April 2009, two m

19 May 2009

Genzyme Science Center Framingham, Massachusetts, USA



Genzyme Corporation is one of the world's leading biotechnology companies, which has been in operation since 1981. G

11 November 2008

Amylin Pharmaceutical – West Chester, Ohio, USA



Amylin Pharmaceuticals is a biopharmaceutical firm located in San Diego, California, with over 1,000 employees in the US

23 September 2008

Pharmstar Pharmaceuticals Plant, Rocky Mount, North Carolina



PharmStar Pharmaceuticals Inc is a relatively new drug manufacturer, which is headquartered in Rocky Mount, North Caroli

16 September 2008

Sanofi Pasteur Vaccine Plant, Val De Reuil, France



Sanofi Pasteur, the vaccines division of Sanofi Aventis, is focusing on a continuing technology upgrade and expansion. T

4 September 2008

Merck And Co Vaccine Facility, Carlow, Ireland



Merck Sharpe and Dohme, the world's seventh largest pharmaceutical company, has a highly successful vaccine division

27 August 2008

Cipla Medpro Pharmaceuticals, South Africa



Cipla Medpro Pharmaceuticals is listed on the Johannesburg Securities Exchange and is one of South Africa's top ten and

29 July 2008

Rentschler Biotechnologie, New Manufacturing Capacity



Rentschler Biotechnologie GmbH is a full-service contract manufacturer and part of the Rentschler Group based in Lauphei

22 July 2008

Accucaps Industries, Manufacturing Capacity – Canada



Accucaps Industries is a contract manufacturer for the soft gelatine encapsulation of pharmaceutical and nutritional compounds based in North America. The company has been in operation since 1989.

16 July 2008

Biopolis Biomedical Research Hub, Buona Vista



The Biopolis in Singapore is a custom-built biomedical research and development hub at One-North, Buona Vista. Situated on 183ha, One-North will be developed over 15-20 years.

19 June 2008

Genentech Cell Culture Plant No 2 Expansion



Genentech is one of the most successful biotech companies on a world scale with four drugs prominent on the commercial m

8 June 2008

Shanghai CP Guojan API Production Suite, Shanghai



Shanghai CP Guojian Pharmaceutical Co Ltd (CPGJ) is a biopharmaceutical company that was formed in January 1998. The com

27 May 2008

Bristol-Myers Squibb – Clinical Supplies Manufacturing



Bristol-Myers Squibb (BMS) has been undergoing much the same rationalisation process as many large pharmaceutical compan

22 April 2008

Boehringer Ingelheim Pharmaceutical R&D Building, Biberach, Germany



Boehringer Ingelheim is a Germany-based company with interests in pharmaceuticals, biopharmaceuticals, chemicals and ani

17 April 2008

Quality Chemical Industries – HIV Drug Plant



HIV, AIDS and malaria are massive problems throughout Africa. The drugs to treat and prevent these diseases are readily

30 March 2008

Novartis Biomanufacturing Plant



Novartis is a multinational pharmaceutical company, based in Basel in Switzerland. The company has plants situated acros

27 February 2008

Bristol-Myers Squibb



In 2006, Bristol-Myers Squibb (BMS) announced a major investment of $220m (€176m) for the expansion of its biol

30 January 2008

Abbott Laboratories Biotech Facility, Puerto Rico



Puerto Rico has a growing reputation as a biotech and pharmaceutical hub ('Bio Island') and plays host to manufacturing facilities from the world's largest pharmaceutical companies.

27 January 2008

GlaxoSmithKline Vaccine Manufacturing Facility, Tuas



GlaxoSmithKline (GSK) has had a presence in Singapore since the 1970s with its investment in an antibiotics plant. Since

19 November 2007

Bidachem Active Pharmaceutical Ingredients Plant, Bergamo



Bidachem SPA is one of the major manufacturers of fine chemicals and active pharmaceutical ingredients (APIs) in Italy.

28 October 2007

Medimmune, Biologics Manufacturing Facility



In September 2006 MedImmune, a Maryland-based biologics company working in the areas of infectious diseases, cancer and

14 October 2007

Sanofi Pasteur Vaccine Production Plant, Swiftwater, Pennsylvania



Sanofi Pasteur, the vaccines business of Sanofi-Aventis, is one of the largest seasonal influenza vaccine producers in t

Roche Bulk Active Ingredient Manufacturing Facility, Florence, SC



Roche Carolina is the highly successful US subsidiary of pharmaceutical giant Hoffmann La Roche. Roche has operated a pr

11 October 2007

Genzyme Biomanufacturing Plant



In June 2007, Genzyme Corporation announced the construction of a new biomanufacturing plant in Lyon, France. The compan

11 September 2007

KBI Biopharma, North Carolina Center For Biomanufacturing, Durham, North Carolina



KBI BioPharma, a division of Atlanta-based Kinetic Biosystems Inc, decided in late 2003 that the home of its new contrac

2 August 2007

Cortex Biotech Facility, Missouri



CORTEX, the Center of Research, Technology & Entrepreneurial Exchange, has constructed a new biotech complex to encourag

29 July 2007

Chengdu Vaccine Plant



In early 2007 Technip was awarded a contract by the Chengdu Institute of Biological Products (CDIBP) for the design, con

Bayer Healthcare Pharmaceuticals Plant, Snohomish County, Washington State



Berlex Laboratories LLC based in Bothell, Washington was the US subsidiary of the German pharmaceutical company Schering

4 July 2007

Shanghai Roche Pharmaceuticals, Shanghai



Roche operates in China as Shanghai Roche Pharmaceutical Co Limited, which is a highly successful joint venture operated

21 May 2007

Vetter Pharma-Fertigung, Contract Manufacturing Facility, Ravensburg



Vetter is a leading contract development manufacturing organisation that specialises in the aseptic filling of liquid and lyophilised drugs for international biotechnology and pharmaceutical companies.

15 May 2007

Roche Biotechnology Plant, Basel



Roche's biotechnology plant in Basel opened in May 2007. The plant was developed on the existing Roche production site,

8 May 2007

Genzyme Manufacturing Expansion, Waterford



Genzyme Corporation is one of the world's leading biotech manufacturers and announced the establishment of a manufacturi

1 May 2007

Biosite HQ and Manufacturing Campus, Mera Misa, California



The Biosite headquarters and manufacturing unit in Mera Misa, San diego, California was completed in August 2006. Biosi

30 April 2007

Novo Nordisk Plant Expansion Tianjin



Novo Nordisk has had research and production facilities in China since 1994 when the company set up Novo Nordisk (Tianji

28 January 2007

Novoseven Facility, Hillerød



The NovoSeven pharmaceutical facility in Hillerød, Denmark was constructed by NNE (Novo Nordisk Engineering), the e

3 December 2006

Eli Lilly Biotech Pilot Plant, Indianapolis



In October 2006 Eli Lilly completed the first phase of its biotech facility expansion in Indianapolis, which was made re

29 November 2006

Biolex Therapeutics Facility Expansion, Pittsboro, North Carolina



Biolex Therapeutics is a biotech company involved in the development and commercialisation of complex proteins and monoc

24 October 2006

Genzyme Flanders NV, Biopharmaceutical Plant Expansion, Geel



Genzyme Flanders is a European subsidiary of the US biotech giant Genzyme Corporation. The 70,000ft² facility in Ge

3 October 2006

Hovione Manufacturing Plant, Loughbeg, County Cork



The production plant at Loughbeg in County Cork, Ireland, is currently owned by Hovione.

10 September 2006

Cook Pharmica Biotechnology Plant



Cook Pharmica LLC, the newest Cook Group company, completed the construction of a $70m biotechnology facility in Blo

Merck Vaccine Plant, Durham, NC, USA



Merck's 272,000ft² vaccine production plant is located on a 262-acre site in Treyburn Corporate Park on the north s

17 July 2006

Stirling Pharma Pharmaceutical Production



Stirling Pharma's pharmaceutical plant in North Sydney, Nova Scotia, Canada, on a 300-acre business park was commissione

14 February 2006

Elan Pharma Secondary Pharmaceutical Facility



Elan Pharma is a biopharmaceutical company working in the development of drugs for the treatment of a wide range of ther

12 October 2005

Roche Diagnostics PCR Diagnostic Kits



Roche Diagnostics completed the construction and commissioning of a new manufacturing facility in Branchburg, New Jersey

5 January 2005

Centocor Biopharmaceutical



Centocor, a subsidiary of Johnson & Johnson, announced in July 2004 the investment of €500m in the constructio

14 September 2004

AstraZeneca Symbicort Production Facility, Dunkirk



AstraZeneca France's Dunkirk plant has been sold to Minafin, a subsidiary of the Minakem Group. The acquisition was comp

Genentech Manufacturing Facility (NIMO)



The NIMO (New Idec Manufacturing Operation) in Oceanside, San Diego, was originally built by Idec as the company wanted

29 July 2004

Bavarian Nordic Smallpox Vaccine Facility



The Danish biotech company Bavarian Nordic has set up a new smallpox vaccine production facility in Kvistgård, Nort

1 July 2004

Serologicals Corporation Biotech Production Plant



Serologicals Corporation finished the construction of a new biotechnology production facility in Lawrence, Kansas, US, i

29 June 2004

Eli Lilly Humalog Manufacturing Facility, Carolina



In April 2001 Eli Lilly announced it was constructing a new biotech bulk manufacturing facility in Carolina, Puerto Rico

14 April 2004

Novo Nordisk



Novo Nordisk decided in the spring of 2003 to market the long-acting insulin analogue Levemir (Insulin Detemir) first in

2 March 2004

Merck Sharpe & Dohme Formulation Plant



Merck Sharpe & Dohme, known as MSD Technology Singapore Pte Ltd in Singapore, opened their newest manufacturing facility

20 October 2003

Ferring Pharmaceuticals



Ferring Pharmaceuticals announced its intention in 2003 to build a new production site at Saint-Prex, Canton of Vaud in

1 October 2003

Lonza Biotec



Lonza Biotec completed the construction of new manufacturing capacity with a multi-product design at Visp in Switzerland

28 September 2003

Aventis Recombinant



Early in 2003, Aventis Pharma Germany completed their third insulin plant in Frankfurt, Germany. The new plant produces

21 September 2003

Schering-Plough Production and R&D Facilities



Schering-Plough has continued to capitalise on its investment program into facilities based in Singapore. The company cu

Boehringer Ingelheim



In March 2002 Boehringer Ingelheim opened their new manufacturing facility in Pudong, Zhangjiang High Tech Park in Shang

4 September 2003

Neopharma Pharmaceutical Plant, Abu Dhabi



Neopharma opened a new pharmaceutical plant in Abu Dhabi, United Arab Emirates, in July 2003.

10 August 2003

MSD Biologics Advanced Biologics Centre



Avecia Biotechnology announced a $100m investment in a new advanced centre for biologics manufacture in Billingham,

21 July 2003

VaxGen Biopharmaceutical Manufacturing Plant



VaxGen opened a new biopharmaceutical manufacturing facility in South San Francisco, California, US in June 2003. The fa

30 June 2003

Baxter BioPharma Solutions Parenteral



Baxter BioPharma Solutions is a contract manufacturer of pre-filled syringes, vials and cartridges for the packaging of vaccines and drugs to treat chronic conditions such as rheumatoid arthritis and multiple sclerosis.

19 June 2003

AstraZeneca Biopharmaceutical Manufacturing



DSM Biologics completed the construction of the first phase of a substantial expansion to its large-scale biopharmaceuti

9 June 2003

Lonza Biologics Plant Expansion



Lonza Biologics completed the large-scale expansion of their facility in Portsmouth, New Hampshire, Pease International

2 June 2003

Biogen Idec Pharmaceutical Production Facility



In March 2003 Biogen Idec began construction of its first production facility to be located outside of the USA. The plan

22 May 2003

Boehringer Ingelheim Active Ingredients Plant



Boehringer Ingelheim officially opened the new active ingredients plant in Ingelheim in early 2003. The plant will be ab

4 March 2002

Novartis Diovan Manufacturing Plant, Schweizerhalle, Switzerland



In September 1999 Novartis opened a new pharmaceutical production facility at the Schweizerhalle site near Basel, Switzerland.

3 March 2002

Rohner Custom Synthesis Plant



In March 1999 Rohner AG began the construction of a new state-of-the-art pharmaceutical facility at its existing site at

Amgen Process Development Facility



Bothell is the site of a process development facility owned by the pharmaceuticals firm Immunex (now owned by Amgen).

16 January 2002

Achillion Pharmaceuticals Biotech Facility



Achillion Pharmaceuticals was founded in February 2000 as one of the largest biotech start-ups in the USA.

Amgen Pharmaceutical Manufacturing Facility



West Greenwich, Rhode Island, US, is the site of a new pharmaceutical manufacturing facility dedicated to the production

ChemSyn (Aptuit) Pharmaceutical Manufacturing Plant



ChemSyn Laboratories (now Aptuit), a leading producer of anti-cancer bulk pharmaceuticals and other high potency chemica

15 November 2001

Novartis’ API Plant in Grimsby, West Yorkshire, UK



Novartis Pharmaceuticals' active pharmaceutical ingredients (API) plant complex in Grimsby, West Yorkshire, was first established in 1951.

5 September 2001

Janssen Pharmaceutica’s Pharmaceutical Plant, Geel, Belgium



Johnson & Johnson (J&J) subsidiary Janssen Pharmaceutica decided to build a new pharmaceutical plant in Geel in Belgium in 1998.

MSD’s Manufacturing Plant Expansion, Ballydine Co Tipperary, Ireland



Between 1997 and 1999, Merck Sharp and Dohme (MSD) undertook a two-year expansion of its manufacturing facility in Ballydine Co Tipperary, Ireland.

16 May 2001

Bayer Corporation Biotechnology Plant, Berkeley, California, US



In August 2000, the Bayer Corporation was granted permission by the city of Berkeley to develop an additional 14 acres s

AstraZeneca’s Bulk Pharmaceutical Purification Plant, Guayama, Puerto Rico



In July 1997, AstraZeneca announced plans to invest £15m in its Guayama facility in Puerto Rico.

14 May 2001

GE Healthcare Pharmaceutical Manufacturing Plant, Shanghai, China



In 2000, Nycomed Amersham announced it would open a new pharmaceutical plant in Shanghai on 27 October.

13 May 2001

ImClone Systems Biopharmaceutical Plant, New Jersey, US



In January 2000, ImClone Systems began construction of a new 100,000ft² biopharmaceutical manufacturing facility in Branchburg, New Jersey.

AstraZeneca Pharmaceutical Manufacturing Plant, Wuxi, Shanghai, China



In early 2001, AstraZeneca inaugurated a pharmaceutical plant in the Wuxi region of northeastern China.

Daiichi Sankyo Company, Pharmaceutical Plant, Beijing, China



In June 2000, Daiichi Sankyo Company opened a new pharmaceutical plant in Beijing.

Pfizer’s Bulk Pharmaceuticals Facility, Tuas, Singapore



The large-scale pharmaceutical facility in Tuas, Singapore, is Pfizer's first manufacturing facility in the country.

10 May 2001

Glaxo Wellcome Anti-Infective Drugs Plant, Suzhou, China



In 1998, Glaxo Wellcome made an investment in a production facility in Suzhou in the eastern Chinese province of Jiangsu.

9 May 2001

Trygg Pharma’s Seal Sands Bulk Pharmaceuticals Facility, Teesside, UK



In April 2000, Lundbeck Pharmaceuticals was awarded contracts for the construction of a bulk pharmaceutical facility in Seal Sands, Teesside, UK.

Roche Vitamins and Minerals Premix Plant, Republic of South Africa



Hoffman La Roche completed the first phase of construction for a vitamins and minerals premix plant at Isando, Republic of South Africa, in June 2002.

14 February 2001

Protchem Industries Derivatives Plant, Chennai, India



In 1999, construction began on a derivatives plant for Protchem Industries.

CSL Recombinant Proteins Production Plant, Melbourne, Australia



The CSL Parkville facility has undergone several phases of expansion since 1997 when it was first opened. The production facilities have been expanded three times.

Novo Nordisk Insulin Cartridge, Chartres, France



Novo Nordisk is upgrading the insulin production plant at its facility in Chartres, Eure-et-Loir region, France. The Dan

12 February 2001

Roche Vitamin Plant, Taishan, Shanghai



Roche's latest vitamin plant is located in Taishan, Shanghai, which is in the northeastern part of the Peoples' Republic of China.

11 February 2001

Lonza Niacinamide Production Facility, Iksan, South Korea



Lonza Fine Chemicals and Specialties put a production facility for niacinamide into operation in 1997 following a joint venture (JV) agreement with the Guangzhou Pesticide Factory.

DSM Premix Vitamin Plant, Jalisco, Mexico



Hoffman La Roche built a vitamin premix plant in 2000 at El Salto in Jalisco, Mexico, to expand its operations in the premix vitamin market.

12 October 2000

GlaxoSmithKline Manufacturing and Packaging Plant, Zebulon, NC



In 1999, UK-based pharmaceuticals company Glaxo Wellcome instigated a project to expand its 652,000ft² manufacturing and packaging plant in Zebulon, NC.

Press Release

Regional Offices

Metrohm AG

Oberdorfstrasse 68

9101 Herisau

Other

Switzerland

+41 71 353 8585 +41 71 353 8901 pharma.metrohm.com www.metrohm.com
Close
Close
Close

Go Top